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Optimal postoperative chest tube and pain management in patients surgically treated for primary spontaneous pneumothorax; a randomized controlled trial.

Our objective is to compare the efficacy of early chest tube removal combined with single-shot PVB versus standard treatment (chest tube for at least 3 days and thoracic epidural analgesia (TEA)) after surgery for PSP. Efficacy is defined as…

Study on Prognosis of Acutely Ruptured intracranial Aneurysms

The goal of this study is to investigate which treatment(-s) lead to the best outcome by using existing variation of practice.

The DRAIHA study: Data Registry of AutoImmune Hemolytic Anemia, to improve diagnostic testing for the development of personalized treatment protocols in AIHA patients

Primary objective1. The primary aim of the study is to answer the question whether specification of a positive direct antiglobulin test and/or red blood cell autoantibody specification is correlated with the clinical course in patients with AIHA.…

The beneficial value of 18F FDG PET/CT in the follow-up of stage III non-small cell lung cancer patients

Primary Objective The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F FDG PET/CT versus follow-up with conventional CT surveillance. Secondary…

Accuracy of synthetic CT-images based on MRI-images compared to conventional CT-images for shoulder osteoarthritis evaluation and surgical planning

The objectives are to determine the accuracy and reliability of sCT compared to conventional CT regarding (1) classification ofshoulder osteoarthritis morphology and (2) planning for the 3D-position of a compound used for shoulderreplacement…

A randomized, open-label, multicentric, two-arm pivotal trial of SonoCloud-9 combined with carboplatin (CBDCA) vs standard of care lomustine (CCNU) or temozolomide (TMZ) in patients undergoing planned resection for first recurrence glioblastoma

To evaluate and compare the survival outcome of patients with first recurrence of glioblastoma undergoing surgical debulking/resection followed by either implantation of the SC9 device and repeat BBB opening in association with carboplatin…

The 10-year follow-up of the ESCAPE trial: Do patients with a non-obstructive meniscal tear develop more knee osteoarthritis after knee surgery or after exercise therapy?

To compare the degree of osteoarthritis in the knee after 10 years, in patients with non-obstructive meniscal tear, between meniscal surgery and exercise therapy treatment.

Bifurcation PCI with a hybrid strategy with drug eluting balloons versus a stepwise provisional two-stent strategy. A randomized controlled single-blinded multicentre trial and registry

In this study we will compare a hybrid DEB strategy with a conventional bailout 2-stent strategy (TAP/T-stenting or Culotte) in patients with a bifurcation lesion with sub-optimal side-branch result. The primary endpoint will be the composite…

Antigen specific T cells in advanced human atherosclerosis

The primary objective of this study is to measure the number of antigen specific T-cells in the plaque and in blood, and investigate whether these parameters correlate with the phenotype of the atherosclerotic plaque. Secondary objectives are: 1)…

The safety and cost-effectiveness of discontinuing disease-modifying therapies in stable relapsing-onset multiple sclerosis (DOT-MS): a randomized rater-blinded multicenter trial.

The aim of this study is to identify whether it is possible to safely discontinue treatment in stable RRMS patients who have shown no evidence of active inflammation in the years prior to inclusion in terms of the return of inflammatory disease…

Clinical outcomes and cost-effectiveness of a diagnostic and treatment strategy of upfront CTCA plus selective non-invasive functional imaging compared with standard care in patients with chest pain and suspected coronary artery disease

This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.

Thrombectomy in high-Risk Pulmonary Embolism - Device
versus thrombolysis Netherlands: TORPEDO-NL

To determine whether CDT in high-risk PE relative to systemic thrombolysis is:- more effective and safer in terms of a reduction of the composite endpoint on all-cause mortality and adverse events defined as treatment failure, major&…

Multifactorial Approach Training for Anterior Shoulder Instability in patients undergoing arthrosopic bankart repair: a randomized controlled trial

In this research, we are comparing two distinct physiotherapy treatments as post-operative care following shoulder arthroscopy (Bankart repair). Our aim is to gain a better understanding of how to provide optimal post-operative care for patients…

HypoPRIME

Determine the safety (oncological outcome and toxicity) of an comprehensive treatment combining recent advances in the treatment of high risk prostate cancer

HAKA trial 10 years follow-up

Primary: investigate the (cost-)effectiveness of replacing RFU after THA and TKA at 10 years by COD by comparing the complications and clinical visits between patients with COD versus RFU at 10 years after THA and TKA. Secondary: investigate the…

HAKA trial 1 year follow-up

To investigate the (cost-)effectiveness of COD compared to RFU at 1 year, up to 2 years after THA and TKA.