Search for a trial

Ultrasound-guided resection of buccal mucosal carcinomas - a multicenter study

The aim of this research is to decrease the number of involved margins, resulting in less adjuvant therapy and less local recurrences.

Hydra study

To prospectively validate the safety and efficiency of management according to the YEARS algorithm to safely rule out clinically suspected PE in patients with active malignancy to be compared with `standard' management by CTPA alone in a…

A short scheme of preoperative radiotherapy for soft tissue sarcomas

to compare the short-term toxicity of the conventional schedule of 25 x 2 Gy, once daily fractionation in a five-week Overall Treatment Time (OTT) to 14 x 3 Gy, once daily fractionation in a three-week OTT, with respect to the rate of postoperative…

Pulmonary inflammation and glucocorticoid sensitivity for the prediction of bronchopulmonary dysplasia (PRIDICT-BPD): A multicenter study

To develop a prediction model for BPD using a range of multimodal predictors assessed in the first two weeks of life.

BRAINWAVES

The main aim of this study is to investigate how brain water oscillations measured with NIRS correlate to blood pressure. 

Handgrip exercise in models of IR

To explore the effect of acute local handgrip exercise on the ability to protect against myocardial damage in ex vivo models of myocardial ischaemia-reperfusion e.g. the Langendorff perfused rat heart, isolated cardiomyocytes from rat heart, and…

Physiological-based cord clamping for infants with congenital diaphragmatic hernia: a multicentre randomised controlled trial

Primary Objective: To evaluate whether PBCC results in a reduced incidence of pulmonary hypertension in infants with CDH 24hrs after birth.Secondary Objectives: To measure and monitor physiological parameters during transition to provide…

A Multicenter, Prospective, Longitudinal, Observational Study in Children and Adults with Stargardt Disease Secondary to Mutation in the ABCA4 Gene

Primary Objectives• To evaluate prognostic factors of disease progression in subjects with Stargardt disease secondary to mutation in the ABCA4 gene • To further characterize the STGD1 patient population for future interventional clinical studies

WIDE study

Objective: To identify and characterize WD patients in the Netherlands. Secondary objectives of this study are; describe disease management and treatment patterns, examine treatment adherence and efficacy of current treatment options, gain insight…

Delirium treatment with Transcranial Electrical Stimulation

The aim of the study is to investigate whether standardized or personalized tACS induces EEG changes indicative of delirium reversal (primary outcome) or reduces the duration and/or severity of delirium (secondary outcome) compared to sham…

An Open-label, Randomized, Controlled Phase 3 Study of Disitamab Vedotin in Combination with Pembrolizumab Versus Chemotherapy in Subjects with Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma that Expresses HER2 (IHC 1+ and Greater)

Primary Objectives:Associated pharmaceutical trial:To compare the efficacy of disitamab vedotin in combination with pembrolizumab to chemotherapy as first-line treatment in participants with advanced UC that expresses HER2Clinical…