155 results
This study has been transitioned to CTIS with ID 2024-513412-10-00 check the CTIS register for the current data. Phase 1: • To determine the MTD/RP2D regimen of brigatinib monotherapy when administered in pediatric and AYA patients with ALK+ ALCL or…
This study has been transitioned to CTIS with ID 2024-517846-32-00 check the CTIS register for the current data. To evaluate the effect of prolonged duration of (fos)aprepitant prophylaxis on the prevention of delayed CINV (complete remission in the…
This study has been transitioned to CTIS with ID 2024-514073-22-01 check the CTIS register for the current data. To investigate differences in coagulation between (Omniplasma) and FFP in paediatric cardiac patients, who are undergoing cardiac…
This study has been transitioned to CTIS with ID 2024-513843-10-00 check the CTIS register for the current data. Primary objective: Assess the short term safety and tolerability of 68Ga-SATO in pediatric patients with NBLSecondary objectives: -…
The aim of this study is to investigate the scar quality in a paediatric burn population treated with Glyaderm up to 12 months after surgery.
This study has been transitioned to CTIS with ID 2024-515499-12-00 check the CTIS register for the current data. The primary objective is reducing treatment-related morbidity and mortality without adversely impacting DFS in Ph+ ALL patients,…
This study has been transitioned to CTIS with ID 2024-513041-37-00 check the CTIS register for the current data. Primary objective of this study is to significantly reduce relevant (moderate/severe) parenchymatous brain injury on postoperative MRI…
To investigate the role of talkers* voices in speech communication in NH, HI, and CI children and adult listeners, and how the perception of talker voice information relates to the processing of indexical and linguistic information among these…
The main objective of this longitudinal study is to gain insight into the neurodevelopmental trajectories following neonatal critical illness, from the perinatal period to school-age compared to healthy controls. This insight may lead to the…
This study has been transitioned to CTIS with ID 2024-516123-13-00 check the CTIS register for the current data. Part I:Primary Objective: Evaluate the effects of tiratricol on neurodevelopment in young MCT8 deficiency patients, as measured by the…
This study has been transitioned to CTIS with ID 2023-510009-16-00 check the CTIS register for the current data. Primary Objectives:• Phase 1 Only: To determine the recommended Phase 2 dose(RP2D) of quizartinib, in combination with chemotherapy,…
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…
Primary: To describe safety and tolerability during longer-term administration of AR101 and follow-up observation after the last dose of AR101.Secondary: - To assess the level of desensitization achievable through extended maintenance dosing of…
• Primary Objective: To evaluate the effect of azacitidine treatment in AML subjects at molecular relapse after CR1 with regard to molecular response prior to further treatment (reinduction / HSCT)• Secondary Objectives:o To assess safety of…
The primary objective is to assess the hypoxic challenge test, combined with echocardiography, as a function test for the pulmonary and pulmonary vascular system in preterm born children with and without bronchopulmonary dysplasia. Secondary…
Primary: Is OIT with standard food products safe to perform in children aged 9 to 24 months with a proven food allergy for hen's egg, peanut, cow's milk, cashewnut, hazelnut, walnut and/or one of the more rare allergens (as soy, pits and…
The aim of our project is to establish the feasibility, effectiveness, costs and acceptance of early case finding of CD in children attending the YHCCs in a well described region in the Netherlands, using a POC test for TG2A determination.…
This study has been transitioned to CTIS with ID 2024-514917-36-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Rx-induction: Comparison of the 3 year EFS rate of 2 induction regimens, GPOH and RAPID COJEC, in patients with high-…
Objective: We propose the Amsterdam Infant Microbiome Study (AIMS). The general objective of AIMS is to establish a research infrastructure that allows for explorative research on the development of the microbiome in relation to healthy growth and…
To determine the burden of disease due to RSV in young term born infants.The active cohort study is expanded to other family members during the COVID-19 pandemic to gain insight in COVID-19 related burden to families. In addition we would like to…