255 results
This study has two parts. The main objective of part 1 (in vivo) is todetermine changes in markers of oxidative stress in exhaled breath as a result of different short term oxygenation strategies (liberal versus conservative) . The main objective of…
The main objective of this proposal is to establish ex-vivo models of bronchial epithelial cells from children. Use of (1) epithelial organoid cultures derived from bronchial or nasal epithelial cells; and of (2) bronchial brushings; (3) nasal…
Primary objective:- To study the impact of community acquired pneumonia in children on persistent symptoms and quality of life, from admission in hospital until one year after discharge.Secondary objectives:To investigate/assess:- The association…
The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…
Primary objective• To characterise natural disease progression rates of MRI- and/or US-assessed measures of muscle properties and muscle function and strength tests in children with neuromuscular disorders through standardized annual follow-up…
With this study we aim to increase our understanding of perinatal mental health in migrant and refugee mothers, exploring potential risk and protective factors for PMCs from pregnancy up to 6 months after birth. We also aim to explore the…
The aim of SPIRIT is to investigate the mechanisms of the immunological tolerance to FVIII in patients with hemophilia A aged younger than 18 years using NFT for prophylaxis.
To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age
The primary aim of the study is to assess the overall health of offspring born to a mother with solid organ transplantation, and to identify possible pre- and perinatal risks for diseases later in life. In addition, we would like to collect and…
We aim to define the growth trajectory of clonal hematopoësis after allogeneic transplantation, and identify potential modulating factors.
To determine the real world response to standard of care CAR T-cell therapy, in order to better understand the intrinsic and extrinsic factors related to treatment success or failure.
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…
The aim of this study is to compare the outcomes after three different surgical techniques, namely straight line closure, Z-plasty closure and closure using cheek flaps, with regard to speech outcomes and postoperative complications by means of a…
Therapeutic nadroparin administration:Primary objective: To develop evidence-based dosing regimens of nadroparin for children in different age groups by means of the objectification of the PK/PD of nadroparin.Secondary objective: 1) Investigate the…
Our primary objective is to collect normative reference values in typically healthy developing children, aged 0 - 18 years, for EEG in combination with ERP and eyetracking, and OCT measurements (For details see also paragraph 5.1).