255 results
This study has been transitioned to CTIS with ID 2022-501457-37-00 check the CTIS register for the current data. Primary Objective:- Achieving an event-free survival, which is not inferior to the ML-DS 2006 trial (87±3%)Secondary Objective(s):-…
Primary Objective:To investigate change in fat mass index between 6 and 12 months of age in infants receiving Nuturis® formula feeding versus standard formula feeding during the first 6 months of life.Secondary Objectives:- To investigate change in…
The aim of this study is to analyze (in)activity, sleep quality and sleep duration of children during clinical admission in the Amsterdam UMC (Acute Admission Unit and regular nursing wards) in comparison with the normal situation at home.…
Primary Objective: Prenatal and postnatal growth trajectories and prenatal maternale exposures, type of feeding, appetite regulating hormones and (epi)genetic factors in association with body composition at ages 1,3, 6 and 9 months and 1 year, 18…
The aim of this study is to identify genetic determinants that are associated with successful immune tolerance induction in patients with haemophilia A and inhibitors.
This study has been transitioned to CTIS with ID 2023-504880-18-00 check the CTIS register for the current data. Primary• To determine the RP2D of crizotinib in combination with temsirolimus • To determine the safety and preliminary activity of…
In the present randomised double blind controlled study, we will study the effects of GOS or FOS vs a placebo on stool consistency. Other parameters to be investigated include stool frequency, stool consistency in number of cases (%), painful…
This study has been transitioned to CTIS with ID 2024-512321-84-00 check the CTIS register for the current data. Primary objectives:Evaluation of efficacy of multispecific T-cell transfer in patients with chemo-refractory viral infections after…
In the present randomised double blind controlled study, we will study the effects of GOS vs a placebo on stool consistency in children with hard or lumpy stools. Other parameters to be investigated include stool frequency, stool consistency in…
(1) To assess parent-child attachment and interaction in a cohort of children and adolescents known with IF and (a history of) home PN dependence, and (2) to assess cognitive development and social-emotional functioning in these children.
The main research objectives for the proof-of-concept study are to show the feasibility and safety of a daily cycle of feeding and fasting in critically ill children of different age-groups, that will trigger an adequate fasting response while…
primary objectives- To asses sequelae of COVID-19, at 4 to 12-months following a COVID-19 diagnosis among pediatric patients receiving care in the hospital or outpatient setting in the Netherlands.- To determine risk factors for long-COVID among…
This study has been transitioned to CTIS with ID 2024-512657-24-00 check the CTIS register for the current data. Stratum 1:To show that a non total body irradiation (TBI) containing conditioning (Flu/Thio/ivBu) results in a non inferior survival as…
To investigate the impact of different levels of anesthesia exposure on children*s neurocognitive development and evaluate the concurrent validity of different methods to assess neurodevelopmental outcome.
Our overall aim is to assess the seroprevalence of SARS-CoV-2 antibodies in an international population of pwCF and to examine associations between SARS-CoV-2 infection and clinical risk factors for infection, as well as subsequent clinical outcomes…
This study has been transitioned to CTIS with ID 2024-518652-23-00 check the CTIS register for the current data. Investigating the long-term safety of personalized cholic acid treatment in patients with defects in bile acid synthesis based on…
The aim of this study is to evaluate if a PPT can significantly decrease - or possibly prevent - the collapse of the trachea in newborns with EA and moderate or severe TM. Additionally, the study aims to determine whether the observed effect of PPT…
The aim of this study is to establish the accuracy of Molecular Culture for prediciting the outcome of the traditional blood culture.
The Primary Objectives of the Phase 1b are: • To assess the safety and tolerability of carfilzomib, alone and in combination with induction chemotherapy, for the treatment of children with relapsed or refractory ALL • To determine the maximum…
This study has been transitioned to CTIS with ID 2023-506269-78-00 check the CTIS register for the current data. Objectives for Part 1: Primary (Efficacy): To demonstrate that the efficacy of fenfluramine (ZX008) 0.8 mg/kg/day is superior to placebo…