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A randomised, single blinded, prospective, observational study of molecular biological effects of xenon inhalation used for early preconditioning in humans undergoing coronary artery bypass grafting

The aim of this study is to evaluate cardio-protective effects of xenon inhalation in humans and to identify enzymes contributing to cardio-protection influenced by xenon in patients scheduled for CABG surgery.

A multi-center, double-blind, parallel-group, placebo-controlled, randomized study: evaluation of the efficacy and safety of brivaracetam in subjects (16 to 70 years old) with Partial Onset Seizures.

To evaluate the efficacy of BRV at the doses of 20, 50 and 100 mg/day in b.i.d. administration in reducing seizure frequency in subjects with partial onset seizures not fully controlled despite optimal treatment with 1 to 2 concomitant AED(s),…

Effects of insomnia and chronic use of hypnotics on driving performance

Aim of the study is to investigate what the influence is of insomnia on driving performance and to what extent this influence is attenuated by the use of hypnotics. Therefore, over-the-road driving performance of treated and untreated patients…

The effect of bevacizumab on taxanes-mediated release of growth factors and bone marrow derived endothelial progenitor cells.

This study has two primary objectives:To determine the effect of taxane therapy on the release of bone marrow derived endothelial progenitor cells.To study the effect of bevacizumab on taxane induced release of bone marrow derived endothelial…

User evaluation of the 'free style Navigator continuous glucose monitoring system

The objective of the study is the assessment of the effect of the use of the 'free style navigator continuous monitoring system' on the glucose variability in patients with type 1 diabetes mellitus. This assessment is combined with the…

Possibilities of a muscle transfer to replace absent hip abductors after Total Hip Arthroplasty (THA)

The primary goal of this research is to study the effect of several simulated muscle transpositions in patients with a hip abduction weakness, caused by a total hip arthroplasty. With the use of a musculoskeletal model of the lower extremities, it…

A phase IV, long-term, open-label, multicenter extension study to evaluate the safety and tolerability of ranibizumab in subjects with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD)

Evaluating the long term safety and tolerability of ranibizumab treatment of AMD patients.

A Multicentre, Double-Blind, Double-Dummy, Two-Phase Crossover Study of Nasalfent (Fentanyl Citrate Nasal Spray) Compared to Immediate Release Morphine Sulphate Tablets in the Treatment of Breakthrough Cancer Pain (BTCP) in Subjects Taking Regular Opioid Therapy

Primary: To demonstrate the superior efficacy of Nasalfent in the treatment of BTCP in opioid tolerant subjects who are receiving regular opioid therapy.Secondary: To demonstrate the safety, tolerability, and acceptability of Nasalfent in the…

A multi-center, randomized, double-blind, placebo and active controlled, parallel group, dose range study to evaluate the efficacy and safety of LCZ696 comparatively to valsartan, and to evaluate AHU377 to placebo after 8 week treatment in patients with essential hypertension

The primary objective of this study is to determine the efficacy and safety of different doses of LCZ696 compared to valsartan. In addition, the efficacy and safety of AHU377 as compared to placebo is evaluated.

Multicenter, randomized, double-blind, placebo-controlled study to evaluate the effect of ITF2357 on mucosal healing in patients with moderate-to-severe active Crohn*s Disease.

Primary objective of the study is to determine the ability of ITF2357, administered orally at the dose of 50 mg b.i.d. for 8 consecutive weeks, to induce complete healing of mucosal ulcerations of ileum and/or colon, assessed by endoscopy,Secondary…

A Randomized, Double-Blind Study Comparing the Safety and Efficacy of Once-Weekly Administration of Etanercept 50 mg, Etanercept 25 mg, and Placebo in Combination With Methotrexate in Subjects With Moderately Active Rheumatoid Arthritis Who Have Achieved an Adequate Response With Etanercept 50 mg Once Weekly and Methotrexate

To compare the efficacy of the combination of etanercept 50 mg once weekly with that of the combination of etanercept 25 mg and that of MTX monotherapy at week 88 in subjects with moderate RA who have achieved low disease activity or remission after…

Video-feedback Intervention to promote Positive Parenting for Autism

The effectiveness of Video feedback Intervention to promote Positive Parenting for Autism (VIPP-AUTI) will be investigated on the sensitivity for autism spectrum disorders (ASD) in parents of a child recently diagnosed with ASD, based on the the…

A randomized double-blind phase III study of RAD001 10 mg/d plus best supportive care versus placebo plus best supportive care in the treatment of patients with advanced pancreatic neuroendocrine tumor (NET)

To determine whether treatment with RAD001 10 mg/d plus best supportive care prolongs the progression free survival (PFS) compared to treatment with Placebo plus best supportive care in patients with advanced pancreatic neuroendocrine tumor.

Disease modifying activity of celecoxib on articular cartilage in osteoarthritis

To evaluate, in patients with end stage knee osteoarthritis, the in vivo disease (tissue structure) modifying activity of celecoxib, as a selective COX-2 inhibitor, in addition to its inflammation regulatory properties, compared to naproxen as a…

A comparison of remifentanil patient-controlled analgesia with epidural analgesia during labor

The main objective of this study is compare the analgesic efficacy and safety of remifentanil, administered as patient-controlled analgesia (PCA), with epidural analgesia.

Laminectomy without or with dorsal fusion for cervical myeloradiculopathy:
a (multi center randomized trial)

Cervical myelopathy is caused by static components like stenosis, and probably worsened by movement. From this point of view, decompression with fusion will have better clinical results when compared to decompression solely. In literature,…

The effects of CasiGold and CasiMax on blood pressure in subjects with high-normal blood pressure or mild hypertension

The primary objective is to demonstrate a blood pressure lowering effect of CasiGold and CasiMax in subjects with high-normal blood pressure or mild hypertension. The secondary objectives are to collect human safety data after treatment with…

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Dose Ranging Study to Investigate the Safety and Efficacy of JNJ-16269110 in Overweight and Obese Subjects

The primary objective of the study is to find the appropriate, clinically relevant dosages (among the 5, 10, and 15 mg twice-daily dosages) of JNJ-16269110 by assessing mean changes in body weight from baseline to Week 12, compared to placebo .The…

A phase-I, double-blind, randomized, controlled study on the tolerability and early efficacy of hLF1-11 in hospitalized patients with bacteremia due to Staphylococcus epidermidis.

To establish the safety, tolerability, and early efficacy of multiple doses of hLF1-11 given once daily for 10 days

Safety and efficacy of hLF1-11 for the treatment of infectious complications among haematopoietic stem cell transplant recipients.
Part B: Clinical Study Protocol SC13: Safety of a 5 mg dose of hLF1-11 given for 10 consecutive days to autologous haematopoietic stem cell transplant recipients

To establish the safety and tolerablity of multiple doses of hLF1-11 given once daily for 10 days.