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Efficacy and feasibility of the combination of everolimus and capecitabine in patients with metastatic or locally advanced pancreatic carcinoma

The primary objective of this study is to determine the efficacy and feasibility of the combination of everolimus and capecitabine in a group of patients with metastatic or locally advanced pancreatic cancer.

A study of beneficial and adverse effects of Dermabond tissue adhesive for episcleral explants in retinal detachment surgery.

Evaluation of the hypothesis that outcomes of Dermabond tissue adhesive and conventional suturing for securing episcleral explant in retinal detachment surgery are equivalent.

A phase-I, double-blind, randomized study on the tolerability and early efficacy of hLF1-11 in hospitalized patients with proven candidaemia.

To establish the safety, tolerability, and early efficacy of multiple doses of hLF1-11 given once daily for 14 days.

The effect of fruit and fruit juice on plasma total antioxidant capacity

The aim of the present study is to compare the effect of consumption of a fruit beverage on plasma antioxidant capacity with that of the consumption of fruit.

A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multi-center, International Study to Evaluate the Efficacy and Safety of Oxabact(TM) to Reduce Urinary Oxalate in Subjects with Primary Hyperoxaluria.

Primary Objective:To evaluate the efficacy of Oxabact TM to reduce urinary oxalate levels from Baseline to Week 24 in subjects with Primary Hyperoxaluria (PH).Secondary Objectives:To evaluate:* Percentage of subjects who have 20% or greater…

The effect of neoadjuvant treatment of colorectal cancer with simvastatin on the expression and activation of elements of the Bone Morphogenetic Protein pathway.

Does oral simvastatin at standard doses alter BMP pathway signalling in colorectal cancer specimens in humans?

A randomized, double blind, placebo-controlled, double dummy, three-way crossover study to investigate the effects of an intravenous ethanol clamp and a morphine infusion on resting state functional magnetic resonance imaging in healthy male volunteers

Primary Objectives:• To investigate the effects of a stable level of alcohol (0.6 g/L) on fMRI activation patterns in healthy male volunteers,• To investigate the effect of a stable level of morphine (80 nmol/L) on fMRI activation patterns in…

The effectiveness of intensive treatment on sympathetic hyperactivity. A randomized, cross-over trial in patients with chronic kidney disease and hypertension

The primary objective is to investigate if there is an incremental inhibiting effect on MSNA by increasing dosage valsartan above the presently advised dosage. We hypothesize that there will be a further decrease in MSNA as compared to the MSNA…

Adherence improvement in glaucoma patients

To study the effect on intraocular pressure in patients using the Travalert dosing aid with or without the additional use of the Eyot and with of without additional patient education.

Treatment of Hidradenitis Suppurativa with a blue light (415 nm) and red light(633 nm) combination PDT

Investigate the treatmentefficacy of a red light (633 nm) and blue light (425) combination PDT in HS.

Does stress impair the inhibition of task-irrelevant emotional distracters during working memory?

Primary Objective: Using functional neuroimaging to assess differences in brain activation during WM at low and high load with emotional versus neutral distracters in participants with PTSD and in healthy participants with and without stress.…

A Double-Blind clinical trial of Benfotiamine Treatment in Diabetic Nephropathy

-To investigate whether a short-term treatment (3 months) with benfotiamine in diabetic nephropathy patients leads to a reduction in urinary excretion of β2-microglobulin and albumin.-To investigate whether short-term treatment (3 months) with…

A Double-Blind, Randomized Study to Evaluate the Efficacy and Safety of Lapaquistat Acetate 50 mg versus Placebo in Subjects with Hypercholesterolemia, With an Optional Open-Label Extension

The main objective of this study is to further determine the efficacy of lapaquistat acetate 50mg compared to placebo during a period of 12 weeks. This period is followed by an optional 48 week open label extension to be able to study the long term…

The (cost-)effectiveness of mindfulness-based cognitive therapy and cognitive-behavioral treatment in adolescents and young adults with deliberate self-harm

To study the effects and costs of the total individual CBT package and one of the components of the total CBT treatment package (i.e. mindfulness training) in a group format compared to Treatment-as-Usual (TAU) on the short and long term.

A Phase II, international, multi-centre, prospective, randomised, parallel-group, double-blind, dose-ranging, placebo-controlled, 12-week, princeps study to assess the efficacy and safety of a one injection cycle with either botulinum toxin type-A (Dysport® 125, 250 or 500 units) or placebo followed by an optional 6-month extension phase in the symptomatic treatment of micturition urgency and frequency in continent female subjects suffering from idiopathic overactive bladder.

Primary Objective: To assess the effect of treatment with three doses of botulinum toxin type-A (Dysport®) versus placebo on the number of episodes of urgency and frequency of micturition experienced in continent female subjects with idiopathic…

Feasibility of neurocognitive testing in healthy children

The primary objective is (1) to establish the feasibility of using these neurocognitive tasks in children, and (2) to establish intra-individual variance of task results upon test repetition.The secondary objective is to assess how children have…

A 12-Week, Double-Blind, Randomized, Placebo-Controlled Study in Type 2 Diabetes Mellitus Subjects to Evaluate the Efficacy, Safety and Tolerability of MTP Inhibitor JNJ-16269110

The primary objective of this study is to evaluate the effect of 12-week treatment with JNJ-16269110 on the glycated hemoglobin (HbA1c) concentration in subjects with T2DM.Additional objectives are to evaluate the effect of JNJ-16269110 on:1.…

A Phase 3, Multicenter, Randomized, Double-blind Study Comparing the Safety and Efficacy of ABT-874 to Methotrexate in Subjects with Moderate to Severe Chronic Plaque Psoriasis.

To compare the short-term and long-term clinical efficacy, safety and tolerability of ABT-874 compared to MTX in the treatment of moderate to severe chronic plaque psoriasis over a 24 and 52-week period.

RANDOMIZED PHASE II/III STUDY OF SECOND-LINE ENDOCRINE TREATMENT FOLLOWED BY CAPECITABINE VERSUS CAPECITABINE FOLLOWED BY ENDOCRINE TREATMENT IN PATIENTS WITH METASTATIC ER POSITIVE BREAST CANCER

This trial studies the effects on quality of life and on time to second progression of the sequence endocrine therapy-capecitabine versus the sequence capecitabine-endocrine treatment. It is anticipated that the time on study (which is the time…

Effect of droperidol 2,5 mg added to 100 mg morfine in PCA therapy in combination with ondansetron and dexamethasone against PONV.

The aim of the study is to investigate the surplus value of droperidol on top of het combination ondansetron and dexamethasone.