511 results
Primary objective:The study has hierarchical co-primary objectives to demonstrate that:- Firstly: dexmedetomidine is at least as effective as sedation with midazolam and daily sedation stops, in maintaining a target depth of sedation in ventilated…
To evaluate the anti-tumor activity of a docetaxel/carboplatin regimen in patients with refractory or relapsed SCLC. Furthermore to asses the safety profile of the docetaxel/carboplatin combination.In patients who have experienced FN, the efficacy…
Primary Objective: Compare the overall survival (OS) of patients receiving gemcitabine plus AG-013736 versus gemcitabine plus placebo.Secondary Objectives: 1. Compare the progression free survival (PFS) of patients in each arm;2. Compare the…
The purpose of this study is to determine the effects of a strength training program on physical functioning in children with CP.
1) To assess the antitumor activity of PHA-739358 administered as IV infusion according to two different dose schedules in metastatic HRPC patients progressing on standard docetaxel-based chemotherapy.2) To have a precise idea of the antitumor…
Does chronic nocturnal ventilatory support at home after acute respiratory failure treated by (N)IV lead to a prolongation in time to readmission to hospital due to any following exacerbations in these patients compared to medical treatment only?
To determine whether rate change is feasible and has a positive influence on the effect of SNS on the symptoms measured with voiding diaries.To investigate whether there are differences between optimal stimulation settings between patients with SNS…
Core:1. Quantify vigilance using a portable task battery three times daily during 7 days while subjects are outside the hospital 1.1 Comparing narcoleptic patients to controls 1.2 Comparing narcoleptic patients before and after treatment with sodium…
The aim of the current study is to investigate the effectiveness of the psycho-educational program started at nursing home Klevarie for stroke-patients and their caregivers in expanding their: knowledge about a stroke and its consequences;…
The objective of this study is to determine the efficacy of multiple intravenous infusions of MORAb-003 in platinum-sensitive subjects with a first relapse of epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer) within…
The primary hypothesis of the study is that the use of icodextrin leads to a reduction in extracellular volume compared to glucose 2.27%, but that the effects of icodextrin and glucose 2.27% on plasma will not differ.
To determine the optimal therapy for patients with pT1-2 pN0 oral and oropharyngeal cancer
To examine whether there is a difference in patients perceived outcome between a posterior cruciate retaining total knee arthroplasty compared with a posterior stabilized total knee arthroplasty.
The objective of the pilotstudy is to develop and evaluate a new combined clinical and home rehabiliation research protocol for stroke patients. This pilotstudy will focus on the (re)learning of ADL and mobility skills. Important questions are:-Is…
The objective of this study is to find out is the way contractions are maesurent during labor are of any influence on the lenght and the way women deliver. It also looks if there is any influence on neonatal outcome.
The primary aim of the phase I part of this trial is to establish the safety of a split dose regimen of Re-188-HEDP . The primary aim of the phase II part of this trial is to obtain insight in the efficacy of a split dose regimen of Re-188-HEDP , as…
The primary objective of this trial will be to evaluate the effect of ONO-2506PO (1200 mg once daily) on the slope of respiratory function (slow vital capacity (SVC) expressed as a percentage of the predicted value) over 12 months compared with…
The aim of this study is the comparison of Mindfulness Based Stress Reduction (MBSR), with an empirically proven effective treatment, namely Cognitive Behavioral Therapy (CBT) in the treatment of panic disorders with or without agoraphobia.
The purpose of this study is to provide long-term safety data for Exelon® capsule and transdermal patch treatments, in particular the effect of Exelon® on worsening of the underlying motor symptoms of Parkinson*s Disease (PD), in patients with mild…
The study objective is to evaluate, with respect to hand function, the effect of a physical therapy program based on mirror therapy compared to conventional physical therapy in chronic stroke patients and to improve our understanding of the…