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A randomized, vehicle-controlled, double-blind, Phase I/IIa, multiple-dose, multiple-cohort, Proof of Concept study in Healthy Volunteers and Patients with Cutaneous T-cell Lymphoma to characterize the safety, efficacy, and pharmacodynamics of topical bimiralisib

HV cohort 1Primary Objectives* To characterize the local tolerability of topical bimiralisib after 21 days* To characterize the systemic PK of topical bimiralisib after 21 daysSecondary Objective* To characterize the safety of topical bimiralisib…

Self-management of stress reduction in daily live of individuals with ASD with normal and above average-gifted IQs

The main objective of this study is to develop a prototype mobile apllication to help patients with ADS (normal and above avarege IQ) to detect stress in daily life. The application will not only detect stress, but will help the patient to react o…

Continuous versus Intermittent Nutrition in Paediatric Intensive Care: a Proof-of-concept

The main research objectives for the proof-of-concept study are to show the feasibility and safety of a daily cycle of feeding and fasting in critically ill children of different age-groups, that will trigger an adequate fasting response while…

Vibrating socks: a novel cueing intervention to reduce freezing of gait in Parkinson*s disease.

To test the clinical efficacy of vibrating socks, a new tactile cueing device, for the management of FOG in patients with PD.

A randomized, placebo-controlled, double-blind, parallel arms study to evaluate the pharmacokinetic and pharmacodynamic relationship of multiple subcutaneous injections of apraglutide in healthy volunteers.

1. A better understanding of the apraglutide dose/concentration-effect relationship;2. A better understanding of duration of effect (apraglutide kinetics in relation to citrulline kinetics).

A phase I randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of NPT189 in healthy subjects

The purpose of this study is to investigate how safe the new compound NPT189 is and how well it is tolerated when it is administered to healthy volunteers. NPT189 has been administered to humans before. It has also been previously tested in the…

A phase 1, open-label, non-randomized, 2-period, fixed sequence study to investigate the absorption, distribution, metabolism and excretion of 14C-PF-06651600 and to assess the absolute bioavailability and fraction absorbed of PF-06651600 in healthy male participants using a 14C-microtracer approach

The purpose of this study is to investigate how quickly and to what extent PF-06651600 is absorbed and eliminated from the body (this is called pharmacokinetics). In this study doses of PF-06651600 labeled with very low doses radioactive (14C) will…

Focal Ablative STereotactic RAdiosurgery for Cancers of the Kidney - A Phase II study

The primary objective of this study is to estimate the efficacy of SABR for primary RCC.

A randomized, double-blind, double-dummy, placebo-controlled, 3-way crossover proof of concept study of intradermally administered desmopressin in healthy volunteers using a nanoporous microneedle array.

1) To evaluate the safety and tolerability of MLT*s npMNAs2) To evaluate the pharmacokinetics of intradermal desmopressin administration via MLT*s npMNAs

A Powerful Story- An Evaluation Study of a Life Story Intervention to promote Recovery in People with Personality Disorders in the Third-line Health Care

This evaluation study builds on a preliminary design study, in which 'A Powerful Story' is designed. The primary aim of the current study is to investigate the feasibility of the intervention 'A Powerful Story' in the treatment…

A Phase II basket study of the oral selective pan-FGFR inhibitor Debio 1347 in
subjects with solid tumors harboring a fusion of FGFR1, FGFR2 or FGFR3

Three cohorts will be included consisting of subjects with biliary tract cancer (Cohort 1), urothelial cancer (Cohort 2) and all other solid tumorhistologies not included in Cohorts 1-2 such as NSCLC, head and neck cancer, thyroid cancer, oral…

ASICS trial: Avoiding Sentinel lymph node biopsy In select Clinical node negative breast cancer patients after neoadjuvant Systemic therapy

The primary objective is to evaluate whether SLNB can safely be omitted in breast cancer patients with HER2+ or TN tumors who achieve rCR on MRI after NST. Secondary, quality of life will be assessed in patients with and without SLNB.

A Phase 1 Randomized, Double-blind, Placebo-controlled, Single-dose and Multiple-dose Study Evaluating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of FTX-1821 in Healthy Adult Volunteers and in Patients with Facioscapulohumeral Muscular Dystrophy (FSHD), including an open-label patient cohort.

Part A: Determine safety and tolerability of FTX-1821 in healthy subjects. Part B and C: Determine safety and tolerability of FTX-1821 in FSHD patients.

Study on the pharmacokinetic interaction between diclofenac and tamoxifen in patients with breast cancer. "the DICLOTAM study"

Primary objective1. To compare the Area under the curve (AUC) of endoxifen in patients with breast cancer treated with tamoxifen with and without diclofenac.Secondary objectives1. To compare the Area under the Curve (AUC) of tamoxifen and endoxifen-…

Effects of nicotinamide riboside (vitamin B3) in patients with Ataxia Telangiectasia

The purpose of this research is to investigate whether treatment with nicotinamide riboside (vitamine B3) has a positive effect on the disease course of patients with ataxia telangiectasia.

Randomized, placebo-controlled study to immunomonitor Mycophenolate mofetil (MMF) in healthy volunteers

Objective(s)* To investigate the pharmacokinetic behaviour of a single dose of MMF;o Plasma concentrationso Cellular concentrationso Relationship between plasma and cellular concentrations* To investigate the pharmacodynamic effects of a single dose…

Comparison between the Manometric brace and conventional plaster braces for patients with osteoarthritis of the trapeziometacarpal joint: a randomised crossover trial

The aim of this randomised crossover trial is to compare the Manometric TMC brace with conventional plaster braces in terms of patient satisfaction, pain, hand function, compliance and patient preference.

A Safety, Tolerability, Pharmacokinetic, and Pilot Food Effect Study of Single- and Multiple-Ascending Doses of LY3526318 in Healthy Participants

Primary (Part A)To evaluate safety and tolerability of LY3526318 in healthy participants following a single oral dosePrimary (Part B)To evaluate safety and tolerability of LY3526318 in healthy participants following multiple once-daily oral doses…

A Phase 2a, Double-Blind, Randomized, Placebo-Controlled Study of Ravagalimab in Subjects with Moderately to Severely Active Primary Sjogren's Syndrome.

To evaluate the safety and efficacy of ravagalimab vs placebo for the treatment of primary Sjogren's syndrome (pSS) in subjects with moderately to severely active primary Sjogren's syndrome (pSS).

An Observational, Prospective Multicentre Clinical Study to assess the safety and clinical performance of a New Single-use Negative Pressure Wound Therapy System (PICO 7Y) for the Simultaneous Management of Bilateral Closed Incisions in Oncoplastic Breast Surgery Patients

The aim of this study is to assess the safety and clinical performance (both for patient and doctors) of the PICO 7Y system in delivering NPWT simultaneously to two closed incisions following bilateral oncoplastic breast surgery.