559 results
The primary objective is to obtain OCT data for children aged 4 to 10 diagnosed with non-syndromic craniosynostosis and to compare these to the normal reference values.
The main goal of the study is to evaluate the feasibility of using 1) passive treadmill belt speed perturbations to measure spinal reflex activity in the calf muscles; and 2) active real-time visual feedback on dedicated gait parameters to highlight…
To determine the accuracy of the URIKA urinary bladder sensor in measuring the distance between the anterior - and posterior wall of the bladder and to determine the range in bladder diameters at which the child should be alarmed to void.
The above anounced studies suggest that some abnormalities in the Wnt pathway can be expected to affect development and function of the brain, potentially leading to recognizable behavioural phenotypes. Given the key role of APC in the Wnt pathway,…
Distinguishing frontal lobe epilepsy from ADHD in terms of working memory.
To determine whether the attenuated salivary cortisol response in children with asthma can be explained by the maintenance use of inhaled cortiocosteroids, the chronic inflammatory disease, or the attenuated exercise capacity.
To determine long-term scar quality in patients admitted to a Dutch burn centre with burn wound of indeterminate depth.
To improve diagnostic tools for food/cashew nut allergies with the use of Mediator Release Assays.Genetic component of cashewnut allergy.
Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…
The primary objective is to study the level and time course of the end-expiratory lung volume during the individual incremental * decremental PEEP titration; the secondary objective is to study if there is a significant association between the end-…
Research questions: Primary questions:* Are the new point-of-care instruments for the measurement of VOCs in exhaled breath feasible for use in children and adolescents aged 6 to 20 years?* Are these techniques able to differentiate between healthy…
The main objective is to improve treatment with clotting factor concentrate of patients affected by RBDs by collecting and analysing data on the patients genotype, laboratory phenotype and clinical severity.Secondary objectives are to gain…
The proposed study aims to bring neuroimaging and genetics closer to the child/adolescent psychiatric clinic by developing automated classifiers, and obtain associated multimodal biomarker profiles. Such biomarkers are prospected to, aid in clinical…
The objective of the study is to investigate if it is possible to predict the clinical outcome of a patient with SCN1A related epilepsy based on the findings of advanced genotyping. We aim to answer the following questions:1. Can clinical outcome in…
To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…
The primary objective of this trial are to assess the clinical usefulness (in terms of sensitivity and positive predictive value of 1. Combined heart rate and movement detection2. And the added value of video and audio detection in a population of…
With this research project we will investigate the relationship between SSRI concentration in the (pre)term neonate and clinical short and long term effects on the neonate after exposure to SSRI*s during pregnancy and lactation. Furthermore, the…
To test the hypothesis that salivary pepsin is able to predict outcome of treatment in GERD suspected infants.
The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…
Goal of our study is to compare the CO measuments by the Oesophageal Doppler Monitor (ODM, Cardio Q) with the TPTD technique (PiCCO) and to determine reliability of the ODM in absolute CO values and as a trend monitor. A validation study comparing…