145 results
Primary Objective:Delineate the differences in cellular composition and function at the maternal-fetal interface in patients with SLE compared to healthy women Secondary Objectives:- Establish a novel in-vitro model to study cell-cell interaction at…
The main study objective is to examine the effect of the PTWD program on glycaemic control of lower-educated participants with T2D. The secondary objectives include the effect on medication use, use of care and T2D self-management behaviours. We…
In this study we will confirm that a microbial intervention based on capsules containing autologous (own) lyophilized faecal matter (LFMT), taken daily for 3 month has beneficial effects on residual beta cell function (C-peptide secretion upon MMT)…
The aim of this study is to determine functional parameters of the maternal heart during the lactation period by echocardiography and to correlate these functional parameters with circulating hormones.
Primary Objective: To evaluate cytokine levels in blood samples of human subjects with tinnitus and normal hearing, compared to healthy controls.Secondary Objective(s): To evaluate complete blood count measures (neutrophil count, platelet count etc…
1. To determine the prevalence of cam morphology in a sample of professional female football players.2. To determine the prevalence of other hip related radiological features (e.g. neck-shaft angle, epiphyseal extension, lateral centre edge angle…
The primary objective of this study is to assess if GUD is associated with increased oxidative stress and/or inflammatory markers in the blood. The secondary objectives of this study are to assess whether GUD is associated with decreased working…
To compare dopamine D2 receptor availability before and after a food challenge in patients who underwent successful BS or unsuccessful BS.
The primary research questions are: 1. What is the extent of Adverse and Benevolent Childhood Experiences in frontline staff and treatment staff in general and forensic inpatient psychiatry in comparison to non-clinical staff? 2. To what extent is…
To evaluate in SSc patients with low risk for disease progression 1) whether assessment in an outpatient clinic setting is an acceptable alternative for evaluation in the Care Pathway. Outcome parameters we will evaluate include 1) health care…
1) Assess the whole genome sequence (WGS) and clinical profile of the MPX families to identify how rare and common genetic variants interact to produce shared versus distinct NDDs and clinical features in individuals, or different combinations of…
To investigate the pain phenotype of patients with hand OA. To investigate the prevalence of neuropathic pain symptoms and central sensitization and their determinants in patients with painful hand OA. To investigate the presence of small- and large…
Studies of ex vivo muscle cell autophagy flux, leucocyte mitochondrial function and oxylipins, specifically prostaglandin E2 (PGE2) in critically ill patients during admission to an intensive care unit (ICU).
By acquiring functional MR images and brainstem evoked response audiometry (BERA) from the auditory nuclei in the human brainstem, we expect to observe neurofunctional differences between the subjects with unilateral hearing loss, and subjects with…
Primary: To evaluate the ability to culture PDEC organoids from pancreatic duct biopsies. Secondary: (i) To evaluate ion transport in PDEC organoids derived from pancreatitis patients. (ii) To evaluate the ability of duodenal organoids to mimic ion…
Primairy objective:Explore the prevalence of the ABI-effect, by mapping the participation level. Secundary objective:Substatiate the occurence of the ABI-effect, by mapping cognitive functions of patients and compare these to healthy controls.…
The primary objective of this study is to evaluate the feasibility of MI-E in invasively ventilated critically ill patients. The secondary objective is to evaluate safety and explore data on the efficacy of MI-E in invasively ventilated critically…
Therefore, this study aims to improve the understanding of the physiological effect of VNS on intestinal permeability, intestinal microbiota, immunological parameters in blood and breath in drug resistant epilepsy (DRE) patients. Additionally, this…
Primary objective:To investigate the dose - (clinical) response relationship and therapeutic window of biologics in the treatment of CRSwNP.Secondary objectives:- To investigate the effect of biologics on the sensibilisation pattern of specific IgE…
To evaluate plaque burden and characteristics in early-treated FH patients and to compare coronary plaque burden and characteristics between early- and late-treated FH patients as well as with non-FH controls.