237 results
The purpose of the study is to identify genetic changes that cause gender dysphoria.
• To determine the immunogenicity prediction in PBMCs of patients treated with Infliximab and Adalimumab using the MAPPs assay.• To investigate whether the peptides presented upon in vitro loading of Dendritic Cells are also presented in vivo after…
The primary objective of this study is:- To determine the potential difference in MT and RNFLT between treated and untreated patients with anisometropic or strabismic amblyopia. Secondary objectives are:- To determine the potential differences in MT…
The main objective of this study is to collect DNA within the frame of an existent study to bring together detailed, longitudinal data about adolescents* risk behaviors and peer relationship networks with information on genetic markers. Proposed…
1. To study the mechanisms that control endothelial and platelet secretion using blood outgrowth endothelial cells (BOECs) as an ex vivo model of endothelial and platelet secretion, in order to identify new regulators of and further unravel their…
To gain more insights in the mechanical properties of soft tissue under high risk for deep tissue injury type of pressure ulcers with US and MR Elastography.
The primary objective of this study is to develop an objective, patient-friendly assessment setup with which relevant characteristics of movement disorders of the head, such as CD, can be obtained from video- and depth-images (obtained using…
To analyze the effect of early (12 weeks corrected age) versus late (17 weeks corrected age) introduction of complementary feeding on obesity at the age of 2 years in preterm infants. Furthermore, the effect of complementary feeding on body…
The overall aim of this study is to investigate the pathophysiology of PPMD, and identify predictors of longitudinal outcome.Primary Objective: The primary objective is to investigate the underlying neurobiology of first-onset PPMD using…
The main objective of this project is to study the prevalence of autoantibodies against the NMDA-r, AMPA-r, GABAB-r and VGKC-complex (LGI-1 and Caspr-2) in patients with an early onset psychotic disorder. Patients suffering from stable but also…
The current pilot study aims to investigate whether diversity and composition of the intestinal microbiota are different in patients with enduring anorexia nervosa compared to matched controls. Furthermore, this study aims to explore whether…
1. find out the true time-in-AF per AF category and identify progression of AF,2. uncover genetic predisposing patterns for AF and AF progression,3. find out electrical basis of AF,4. investigate the relationship between genetic changes, electrical…
The objective of this study is to identify biomarkers predictive for the development of HCM in asymptomatic MYBPC3 mutation carriers and to identify prognostic biomarkers in mutation carriers in whom the disease has already been revealed. In order…
The primary objective is to evaluate the effect of UDCA and ezetimibe on cholesterol elimination assessed as total faecal sterol concentration. Secondary objective is to assess the effect of UDCA and ezetimibe on plasma lipid profile/composition.
To search for personalized early warning signals of critical transitions in depressive symptoms within single individuals with a history of depression who wish to taper their antidepressant medication.
This study will investigate the value of C. burnetii-specific whole-blood IFNγ and IL-2 production assays in QFS patients that have either recovered, or are still substantially fatigued. This will show us if these assays can serve as potential…
The influence of Annexin A2 SNP (rs17845226) on von Willebrand factor secretion by endothelial cells
The aim of this research is to study the effect of Annexin A2 SNP rs17845226 on vWF secretion by endothelial cells of controls carrying different Annexin A2 SNP rs17845226 genotypes (WT, homozygous, heterozygous). By testing several endothelial cell…
Primary objectiveTo investigate the presence of plasma abnormalities in treated and untreated patients with ASMD to determine whether they can potentially serve as useful biomarker . Therefore we will determine- sphingolipids and *metabolites-…
The study consists of two parts.Objective 1 to document the day by day changes of tinnitus that participants with intermittent tinnitus experience. This objective is aimed for in part 1 of the study. In addition, this part allows the selection of a…
To investigate FGF19 signalling and metabolic and functional consequences of a disturbed enterohepatic cycle in patients with obstructive cholestasis