282 results
Objective: to investigate calcium containing crystal release in synovial fluid after exercise as drivers of synovitis in post-traumatic versus non-post traumatic osteoarthritis.
The main objective of our Center for Translational Pediatric Pulmonology (CTPP) is to establish models of bronchial epithelial function in children, by (1) epithelial organoid cultures derived from bronchial epithelial cells; (2) bronchial brushings…
The primary objective of the study is to examine muscle atrophy in fetuses with single or bilateral IPEV, in comparison to a normal population by measuring the circumference of the upper and lower legs by ultrasound examination. The length of the…
We aim to investigate, for the first time, differences in frontal activation between healthy elderly people from Okinawa and the Netherlands. We predict that the Western European elderly will show an "MCI-light" pattern, whereas the…
This project aims to provide a deeper understanding of compensation strategies for gait impairments in PD. Specifically, the key objectives are: (1) To correlate the effectiveness of each type of compensation strategy to individual patient…
The aim of this in situ study is to investigate whether occlusal loading leads to increased secondary caries formation in loaded compared to unloaded samples in a near-clinical environment.
Primarily, we aim to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance. To increase the chances of success, the genomic and transcriptomic data obtained in vivo will be integrated with data obtained by a…
In this project we hypothesize that recurrent pregnancy miscarriages is an issue stemming from both the female as the male. The overall aim is to elucidate paternal factors associated with RPL (A) and to assess the predictive value of these factors…
Assessing the post traumatic and degenerative radio-carpal osteoarthritis of open reduction and internal fixation compared with non-operative treatment for elderly patients with an intra-articular distal radius fracture.
1. To evaluate if podocytes directly cultured from the urine, and podocytes derived from induced pluripotent stem cells (iPSCs), can be used to prove causality of the VUS.2. Comparison of results obtained using iPSC-derived and urinary podocytes,…
Primary Objective: Further delineation of the natural history and phenotype/genotype relation of vEDS pateints with a heterozygous pathogenic variant in the COL3A1 gene. Secondary Objectives: 1. reasons for referral for genetic analysis; 2. all…
Aim of the study:To investigate the role of the CD200/CD200R axis on the responsiveness of whole blood, peripheral blood mononuclear cells (PBMCs) and neutrophils to a proinflammatory challenge in the immunoparalysed state in sepsis patients.…
To explore cardiovascular remodelling with subsequent altered cardiac function (assessed as strain rate) in extremely premature neonates (born <30 weeks and/or birth weight < 1000 gram) with FGR.
Main objectives are:1. To explore differences in cerebral perfusion and flow pulsatility between CoA patients and controls.2. To quantify ischemic white matter lesions and cerebral microbleeds in CoA patients with comparison to controls.Secondary…
Our research aims to establish informative tools in the laboratory for studying the molecular and cellular pathways that are altered in SETBP1 disorder.
To investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered every 8 weeks during 6 months through a small intestinal tube, has beneficial effects on residual thyroid function at baseline,…
BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) NL is part of the BIOMAP consortium, which is a EU-funded consortium through which various research projects will address three main unmet needs in AD and Pso with a broad impact on disease…
To investigate the relation between a preoperative abnormal iron status and packed red blood cell transfusion, adverse event and change in disability.To investigate the association of the individual preoperative iron status abnormalities (low iron…
Primary objective:To investigate in Adolescent and Young Adult (AYA) Head and Neck Cancer (HNC) survivors treated with unilateral radiotherapy 5-10 years before, the long-term vascular complications in terms of carotid wall changes (ultrasonography…
Primary objective: To evaluate whether intellectual disability and facial dysmorphology are associated with an increased clinical diagnostic yield of genetic testing among patients with a psychiatric illness.Secondary objective: To investigate the…