44 results
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
Phase 1: Assess reliability of advanced respiratory muscle ultrasound imaging in healthy subjects and congenital myopathies/muscular dystrophies. Phase 2: assess two year follow-up of respiratory function using advanced respiratory muscle ultrasound…
The aim of this study is to investigate the concept of fear of progression among advanced incurable cancer patients onongoing systemic treatment.
Objective: To investigate the adipose tissue response upon ex vivo SARS-CoV-2 infection, more specifically to answer the following questions:1. Is adipose tissue permissive to direct SARS-CoV-2 infection? 2. Are adipose tissue-derived factors…
Primary outcome is to assess HRQoL in high risk and advanced melanoma patients treated with immune checkpoint-inhibitors. Secondary outcomes are to describe anxiety and depression; fear of cancer recurrence; melanoma-specific HRQoL; symptoms and…
The objective of the proposed study is to determine whether the neural mechanisms of word learning change with age. In line with this, we aim to investigate whether the activity of brain regions in this L2 word learning process relate to neural…
The main objective is to assess HRQoL and (disease-specific) symptoms in patients with lymphoma or multiple myeloma. In addition, to identify demographic, clinical, biological, physiological and environmental characteristics of lymphoma and multiple…
Primary Aim: We aim to determine markers for NOX2-mediated insulin-independent glucose uptake signalling pathways, mitochondrial function, myokine secretion both at rest and after a bout of acute exercise in individuals with T1DM and healthy…
The aim of the present study is to investigate the effect of 12-week long daily administration of a sweet orange and pomegranate extract on exercise capacity in healthy adults (40 - 65 y).
Primary objective: To investigate the neuromechanical and sensorimotor principles underlying the multiaxial control of standing balance. Specific sub-objectives of this proposal are:1) To determine how multiple axes of balance control are…
1. To measure clinical outcome of patients with an autoimmune encephalitis longitudinally.2. To evaluate existing PROMS, developed for other (neurological) disease, for patients with an autoimmune encephalitis.3. To develop and validate disease-…
The primary objective is to investigate the course of limitations in physical activity and daily functioning in patients who are diagnosed with unilateral or bilateral vestibular hypofunction, and to identify factors that are associated with this…
The primary objective of this study is to evaluate the feasibility and acceptability of the blended ACT-based intervention among informal caregivers of PWD.The secondary objectives are to evaluate (i) the preliminary effectiveness of the blended ACT…
The primary objective is to assess the causal role of the human amygdala in fear learning, by indexing the impact of TUS targeting the amygdala on physiological markers of fear. The secondary objectives are to (1) discern the neuromodulatory effects…
We aim to determine the effects of collagen supplementation on biomarkers of collagen metabolism in the two weeks following total hip arthroplasty in older adults with osteoarthritis.
Primary objective:o To create a set of sex- and age-specific normative values (graphs and tables) for SRT performance (WRpeak) for healthy Dutch adults, including elderly (aged 25-85 years) (group 1). Secondary objectives:o To determine the test-…
Assessing the feasibility of the research procedures, the burden on participants, the degree of dropout and reason, the interest in participating.What is the main treatment effect for parents / carers motivating them to participate in this study?•…
The study will address two key questions:1. Which brain systems are involved during learning by making predictions versus receiving direct instruction on a numerical fact learning task? 2. Do adolescents and young adults differ in the recruitment of…
The primary objective of this study is to unravel the effects of dopamine D2 receptor stimulation on gating of working memory, reinforcement learning, and reward-based motivation, and their associated physiological changes (measured with fMRI and…
Primary:o To compare effort- and/or reward-related neural activity between cancer survivors and healthy controlso To assess whether cancer-related fatigue is related to effort- and/or reward-related neural activitySecondary objectives:o To assess…