39 results
Primary objective: To determine the characteristics of language, speech and motor functions in MCI due to AD, mild AD and moderate AD Secondary objective: To explore the association between language, speech and motor functions in MCI due to AD and…
The aim of this study is to evaluate the validity of various algorithms for gait bout detection and spatiotemporal measures with a 3-IMU based sensor set worn on the feet and lower back. If this algorithm can be validated, it can be used to obtain…
Primary Objective: To further develop and evaluate a personalised patient-centred surveillance programme including a feedback platform for patients after curative treatment for CRC in terms of health-related quality of life (HRQoL).The goal is for…
The primary aims of this study are therefore to 1) compare DmO2 derived via NIRS between young sedentary, young endurance-trained, older sedentary, and older endurance-trained subjects; 2) to compare non-invasive (i.e. with NIRS and 31phosphorous…
This clinical performance study will evaluate the effectiveness of the Ki 67 IHC MIB-1 pharmDx (Dako Omnis) to identify estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)- early breast cancer patients whose tumours score Ki-67…
Primary: To assess the effects of a 2-week preoperative vegan diet in comparison to an omnivorous diet on protein synthesis rates in Hoffa*s fat pad, synovium, bone, ligaments, menisci, and cartilage in older adults with knee osteoarthritis…
To investigate the production of sufficient numbers of effective CAR/CCR T-cells with T-cells obtained from blood of MM patients.
We aim to lay the fundament of novel interventions by gaining an in-depth comprehensive understanding of individual differences in the overnight adaptation of emotional memory and malleability thereof by noradrenergic modulation.
1. To evaluate the impact of acute worsening events on daily lives of patients with asthma2. To identify and explain the acute worsening associated behaviours, including the underlying reasons for not consulting a healthcare professional.3. To…
The primary objective is to evaluate if and to what extend replacing all meat products in an average Dutch diet with currently commercially available PBMAs affects the systolic blood pressure of middle aged men and women in a 2x8 week fully dietary…
The main aim of the current study will be to determine the metabolic fate of dietary protein. More specifically, the main aim is to assess the incorporation of protein-derived amino acids in a wide variety of organ tissues in vivo in humans.
The main objective is to explore whether digital features of dysarthria, dysphonia, proximal arm fatigue and ptosis can differentiate between participants with and without MG.
Our primary objective is to compare neuroimaging markers on a 3T MRI-scan with the MRI-scans that were performed during TRACK-HD in 2008-2011. We will assess the following neuroimaging markers, starting with the most important marker: 1. Structural…
The main objective is to assess the perceived sound quality of different speech and music excerpts that are modified using the dereverberation algorithm by CI users. To this end a suitable graphical user interface (GUI), the MuSHRA, will be…
In this study we aim to answer the question whether TCR diversity becomes limiting at older age and thereby leads to impaired responses to novel antigens. While many studies have suggested a contraction in TCR diversity with age, a one-to-one…
The primary objective of this study is to determine the femorotibial and patellofemoral weight bearing in vivo kinematics of Journey II BCS TKA patients and to determine correlations that the kinematics may have with patient-reported outcome…
To develop a FOG prediction algorithm under free-living conditions, and to test evaluate the use of the Parkinson*s Vibrating socks under the same conditions
The aim of this project is therefore to measure the effect of the neuro visual rehabilitation and to (re)organize the care from Visio based on the client's request for help and condition.
The general aim of this project is to determine the (cost-)effectiveness of footwear modification in addition to GP-led usual care, compared to GP-led usual care alone for patients with first MTP joint osteoarthritis (OA) at 6 months of follow-up…
Primary:Part A:. Evaluate the toxicodynamic variability in an evenly distributed cohort of male and female healthy volunteers Part B:. Evaluate the toxicodynamic variability among age, sex and ethnic backgrounds Exploratory:. Correlation of flow…