1335 results
Primary objectivesTo confirm that NVA237 50µg o.d. (delivered via a SDDPI) vs. placebo significantly increases trough FEV1 (defined as mean evaluation at 23 h 15 min and 23 h 45 min post dose) following 12 weeks of treatment in patients with…
The main objective of this study is to obtain normal values for high-resolution manometry. The second objective is to investigate the inter- and intra-individual variability of the measured parameters.
To investigate the frequency and the biology of the metabolic syndrome in childhood cancer survivors in order to find risk factors for cerebro- and cardiovascular diseases and to design preventive intervention strategies in indicated risk groups
The goal of the current investigation is to test the noradrenergic part of a new model that accounts better for results of pharmacological research. This model states that the cholinergic system underlies disengagement, and that the…
In this study we will assess the effects of exenatide on cardiac metabolism and function in patients with T2DM and CHF. We will address the following hypothesis: exenatide improves global cardiac function in CHF patients with T2DM, by favorable…
The purpose of this investigation is: • To examine how the new drug FTY720 (study medication) will be absorbed, metabolized and excreted by the body in combination with the contraception pill which consists of ethinyl-estradiol and levonorgestrel.•…
The objective of the study is to evaluate various doses of SSR125543 in first patients (outpatients with a major depressive disorder), evaluate collected information concerning tolerability, efficacy en safety. The same infomation will be evaluated…
The primary objective is to evaluate health related QoL under an oral sequential treatment with natural steroid hormones: Duogestan®. The secondary objective is to evaluate the bleeding patterns over a one-year period.
To determine the influence of the serotonin transporter activity on the plasma free serotonin and dopamine amount and the stored amount (in trombocytes) in three different populations (healthy controls, carcinoid patients and patients on medication…
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The purpose of this study is to compare the effect of AT1001 (migalastat hydrochloride) versus placebo on GL-3 in the kidney.
This study is designed as an extension study to the proof-of-concept trial CAIN457A2206 in patients with psoriatic arthritis and aims to provide continuous treatment with AIN457 for patients in the core trial, to obtain safety and tolerability…
• To evaluate the safety and efficacy of multiple doses of XPF-001 (400 mg bid) for relief of pain in patients with IEM.• To evaluate the efficacy of multiple doses of XPF-001 (400 mg bid) for relief of vasomotor signs in patient with IEM.• To…
To confirm the safety of the Articulinx implant by evaluating device and procedure related adverse events.
To compare Savary dilation with saline 0.9% injections (placebo) with Savary dilation with triamcinolon injections in patients with benign anastomotic esophageal strictures
The aim of this study is to investigate whether exercise changes FVIII levels in patients with moderate and mild haemophilia.
In this study we want to monitor the neurological complications occurring during hip operations, consisting of hip arthroplasty ('head-neck' prothesis) for traumatic hip fractures. We want to establish that there is more understanding of…
Primary: The primary objective of this study is to assess relative to placebo, the efficacyof teplizumab when administered according to 3 different teplizumab dosing regimens in subjects with recent-onset T1DM (within 12 weeks of presentation of…
The objective of the current study is two-fold. First, to identify the duration and severity of back pain in the elderly. Second, to identify possible predictive prognostic factors for developing chronic back pain.
To quantify the effectiveness of one- legged exercise training in improving functional status of patients with COPD in comparison to two- legged exercise training during a 10 week pulmonary rehabilitation programme.