1335 results
- to evaluate the safety and tolerability of a single oral dose of SCH 900229 administered to healthy adult volunteers- to characterize the pharmacokinetic (PK) profile of SCH 900229 in plasma of healthy adult volunteers after a single oral dose- to…
The aim of the research is to gain more knowledge on the influence upper respiratory infections on the course of pregnancies.
The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…
Of each new device it is unknown what the validity is and what the differences (advantages and disadvantages) are compared to the daily used devices.The aim of this study is to answer the question: What is the validity and are the objective benefits…
To establish whether miRNA expression patterns in platelets, monocytes, plasma and endothelial cells differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
This prospective randomised controlled trial makes a comparison between four treatment regiments for mallet injuries without fracture: 1. 6 weeks Stack splint followed by free mobilisation (curent standard splint treatment in ost of the hospitals)2…
For Part A: the purpose of this part is to investigate the effect of multiple oral doses of the new study drug on how quickly and to what extent glimepiride is absorbed and eliminated from the body (this is called pharmacokinetics), if glimepiride…
Primary Objective: To determine whether topical application of rapamycin can lead to reduction in size and/or number of fibrofolliculomas in BHD patients and may prevent the growth of new ones. Secondary Objectives: Safety, formula acceptability and…
The aim of this study is to gain insight in the mechanisms that may be involved in the effects of plant sterol drinks on gastric emptying and gallbladder motility. In order to test this, we compare the different effects of the consumption of a plant…
This study aims to determine the effects of acute coffee consumption compared to consumption of decaffeinated coffee on subjective fatigue and vitality ratings, neuropsychological performance and brain activity during working memory and learning…
The presence of close family members of the patient, who are informed about the exclusion of reversible confounders (e.g. metabolic disturbances, hypothermia or intoxication) and are present at a part of the examinations that are necessary for the…
Primary objectivesPart A of the study (if applicable):1. To assess the safety and tolerability of tosedostat added to standard induction chemotherapy for AMLand select the feasible dose level for part B of the study2. To assess in a randomized…
To evaluate the effect of cholecalciferol supplection on the systolic blood pressure in hypertensive patients with a 25-hydroxycholecalciferol insufficiency. Secondly, the effects on PRA, aldosteron, 25-hydroxycholecalciferol, alkaline phosphatase,…
To study the safety and feasibility of adding 6 weeks of orally administered Pazopanib to 25 x 2Gy in 5 weeks preoperative radiotherapy in soft tissue sarcoma patients (to identify the Dose Limiting Toxicity (DLT) and the Recommend Phase II Dose (…
Objective: To investigate whether binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants or not.
The proposed study aims to develop a prediction rule for response to biological treatment in RA (i.e. effectiveness and adverse events). Guidelines for treating the disease with biologicals using the (derived) prediction rules will be defined. To…
The primary objective of the study is to demonstrate clinically relevant statistical superiority in progression-free survival (PFS) with GClb compared to RClb and Clb alone and RClb compared to Clb [GClb vs Clb; GClb vs RClb; RClb vs Clb] in…
The objective is to determine whether ITB Therapy is more effective than oral anti-spasticity agents in reducing the spasticity.
To compare the impact of adding sitagliptin to usual care vs. usual care without sitagliptin with regard to the risk of developing cardiovascular events.
The goal of this study is to find an efficient early diagnostic and prognostic marker of myocardial ischemia and myocardial infarction. Extended screening of gene expression profiles in circulating progenitor cells in the peripheral blood of…