220 results
Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the response of infection treatment of a prosthetic joint infection.
Primary objectives: - To evaluate the toxicity and feasibility of a preemptive minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination.- To evaluate the effect of a minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination on…
Our study aim is to assess whether MARIA* can provide diagnostic information that can supplement, and in some cases, replace mammography as a tool in the symptomatic workflow. We will also seek patient feedback on this non-ionising, non-compressing…
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
To assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer*s disease-causing mutation by determining if treatment with the study drug slows the rate of progression…
to identify novel molecular pathways resulting in premature atherosclerosis (PAS) in families where the traditional risk factors are not present / near absent.
To study the effect size of FMT after a 3 weeks course of budesonide as induction therapy in patients with active ulcerative colitis despite previous therapy. The purpose of the pre-treatment is to reduce active inflammation prior to donor feces…
Effect of hyperbaric oxygen therapy (HBOT) on patients with chronic neurological deficiency due to stroke.
The primary objective is to measure the level of clinical improvement and quality of life at 6, 12 and 18 months. The secondary objective is to measure functional repair using MRI at 6 and 18 months postoperative. Other important objectives are…
The primary objective of this study is to evaluate the proportion of patients achieving FXI inhibition * 80% at trough (Day 91) after monthly dosing at 3 dose levels of MAA868.
To describe serial changes in diastolic and systolic myocardial performance by comprehensive echocardiographic assessment in neonates prior to, during, and after ECMO treatment and relate this to the course of PPHN.
The main objective of this study is to assess the safety, efficiency, and quality of the steerable punch for future CE-marking
The primary objective of this study is to show equivalence of the total pathological complete response rate (tpCR) in patients treated withHD201 plus chemotherapy to that in patients treated with Herceptin® plus chemotherapy. tpCR will be assessed…
This study aims to provide normative values for sEMG swallow function. Clinicians using sEMG for clinical and research purposes may use this data for a more complete understanding and interpretation of their results. Individual results and changes…
To evaluate the incidence of incisional hernias after stoma reversal after preventive mesh placement compared to no mesh placement. Secondly the incidence of parastomal hernias will be recorded and complications caused by preventive mesh placement…
To analyze the difference in fT>MIC at the target site and infection rate for a single dose of 1 and 2g of cefazolin.
In the present study we aim to test how individual differences in the catecholamines, i.e., highly influential neurotransmitters, dopamine (DA) and noradrenaline (NA) function are related to individual differences in goal-directed behavior in…
To compare the effect of radioactive Iodine or hemithyroidectomy on the symptoms and quality of life (QoL) of patients with a benign euthyroid goiter.
Primary: Part 1: Safety and tolerability. Determine the MTD and/or RP2D of MAK683.Part 2: Anti-tumor activity of MAK683.Secondary: Part 1: Anti-tumor activity. Pharmacodynamics (PD). Pharmacokinetics (PK).Part 2: Safety and tolerability. PK, PD.