1335 results
1. To evaluate the efficacy of a gait training program using an instrumented treadmill with virtual and augmented reality for improving gait adaptability in people in the chronic phase after stroke in an RCT. 2. To identify patient characteristics…
The aim of this study is to determine NET availability in patients with neurodegenerative diseases to characterize NA system degeneration in people with Alzheimer's disease, Parkinson's disease (with and without dementia) and with…
Primary Objective: We want to estimate cut off values for clinically appropriate hypoperfusion of the pharyngeal mucosa and the skin in the neck. Secondary Objective: We want to compare perfusion rate of PTL to perfusion rate in STL in order to…
This study will be a prospective, placebo controlled, randomised phase 2 single centre study with the primary objective to evaluate the safety and tolerability of 2-IB when administered to patients with AIS due to LVO, treated with IVT and/or EVT.…
(1) to create and train an algorithm to generate synthetic CT images of the craniofacial area(2) to evaluate the resulting synthetic CT images in terms of geometrical accurate visualization of the craniofacial osseous structures compared to the…
This study has been transitioned to CTIS with ID 2023-506604-18-00 check the CTIS register for the current data. Primary:- To evaluate the safety and tolerability of SGN-PDL1V in subjects with advanced solid tumors.- To identify the maximum…
Primary Objective: To evaluate cytokine levels in blood samples of human subjects with tinnitus and normal hearing, compared to healthy controls.Secondary Objective(s): To evaluate complete blood count measures (neutrophil count, platelet count etc…
To understand the mechanism of action of OA for the treatment of de novo, severely calcified coronary lesions prior to stent placement using optical coherence tomography (OCT) and to assess stent expansion, based on OCT derived minimal stent area (…
This study has been transitioned to CTIS with ID 2023-509707-32-00 check the CTIS register for the current data. To investigate whether the response rate of pembrolizumab exceeds the response rate of the historic control in locally advanced,…
The primary objective in this trial is to evaluate the use of MRI and contrast enhanced mammography after using MagTrace® to perform a breast conserving surgery and a sentinel node biopsy.
This study has been transitioned to CTIS with ID 2023-507069-25-00 check the CTIS register for the current data. The primary objectives for the study are: Cohort 1, to characterize cardiac safety of different Daratumumab, cyclophosphamide,…
To demonstrate that removal of drains exclusively based on digital drainage system data is non-inferior to additional clamping trials regarding recurrent pneumothorax requiring chest tube reinsertion.
Part 1:Primary Objective- To investigate whether repeated dose GRX-917 reduces panic symptoms elicited by an experimental 35% CO2 -induced fear challenge administered in healthy CO2-sensitive subjects. Secondary Objectives- To investigate whether…
Primary Objective: To assess the safety profile (AEs, SAEs) on combined treatment with tamoxifen and testosterone.Secondary Objectives:• AR to ER ratio on baseline FES- and FDHT-PET imaging (assessed per lesion and per patient by quantitative…
The overall objective of this study is to investigate the potential immunomodulatory effect of sugammadex as seen in previous ex vivo experiments. Specified, the main objective is to investigate the effect of administration of sugammadex without…
3. STUDY OBJECTIVES3.1. Primary ObjectivesThe primary objectives are:• To determine if CAEL-101 and treatment for PCD improves overall survival in Mayo stage IIIa AL amyloidosis patients who are treatment naïve compared to treatment for PCD alone•…
The main objective is to determine function/clinical outcome, measured by the NRS-11 score for pain, 3 months after intervention and compare this between the surgery and conservative group. Secondary objectives are functional outcome as measured by…
To detect differences between ACC patients and controls without ACC, and between the diseased and healthy adrenal gland of ACC patients, in microRNA (miRNA), circulating cell-free tumor DNA (ctDNA), circulating tumor cells (CTCs), and steroid…
Primary objectiveThe primary objective is to evaluate whether a standard pre- and postdilatation of the modern DES results in a more optimal stent implantation compared to DS as evaluated by OCT in patients with stable coronary artery disease.…
Primary Objective: 1. To determine the effectiveness of a personalised, holistic 24-week digital lifestyle programme in achieving diabetes type 2 (T2DM) remission independence from blood glucose-lowering medications, in a Dutch population, in…