16081 results
To evaluate the efficacy of various masking strategies in cochlear implants as a treatment for tinnitus in patients with profound hearing loss.
Our primary objective is to provide a model which accounts for the inconsistencies in the pharmacological literature regarding the role of the noradrenergic and cholinergic system in visuo-spatial attention. Recently we started a University Medical…
The aim of this project is to assess the feasibility of the technology assisted training to improve arm hand skilled performance using the Haptic Master in persons with C-SCI.Research questions:Is it feasible to train persons with a C-SCI with a…
A pilot feasibility study (n=5) will be performed to evaluate the feasibility (logistics, timing) and safety of administering autologous tumor infiltrating lymphocytes (TIL) generated at the NKI-AVL infused in conjunction with systemic high-dose…
Primary objective:To identify the neural mechanisms via which oxytocin modulates social decision-making.Secondary objectives:- To provide an extension of observed behavioral effects of oxytocin on decision-making, specifically to examine decisions…
To determine whether fibrinogen concentrate infusion reduces perioperative blood loss and transfusion in patient experiencing clinically relevant microvascular bleeding during elective complex cardiac surgery and to determine whether its use is safe…
To establish the pharmacokinetic profiles of saliva and plasma concentration of 10 mg MPH-IR and 18 mg MPH-OROS in healthy volunteers; to investigate whether there is a correlation between saliva- and plasma levels of MPH-IR and MPH-OROS, and if…
Primary objectiveThe objective of this pilot study is to test the hypothesis that the use of individual head supports will result in an actual given dose to both the target volumes as well as organs at risk that corresponds better to the planned…
To optimize independent functioning and quality of life through:1. Systematic screening for increased risk of functional loss among community dwelling elderly (Phase 1);2. Providing a nurse-led, complex intervention to elderly people with an…
Please see pages 3-5 of the Protocol
The general objective of this project is to evaluate, for persons with a SCI, on the short and long term, the added value of a behavioural focused intervention, on top of a physical exercise intervention, on the level of everyday physical activity.…
Primary ObjectivesThe primary objectives of this study are to establish:1. The efficacy of internet-delivered SMT for chronic migraine - compared to waitlist control- regarding the post-training improvement of migraine attacks and headache days per…
Investigate how S1 and the premotor cortex modulate the cortico-spinal excitability as measures by single pulse TMS stimulation of M1.
In this study we aim to investigate the long-term results of the prepuberal orchidopexie for the acquired undescended testis. The volume and location of the testis are primary outcome parameters that display the result. This information will…
Primary:To investigate the safety and tolerability of ascending doses of AZD3514 in patients with metastatic castration resistant prostate cancerSecondary: To assess the pharmacokinetics and preliminary anti-tumour activity of ascending doses of…
Tissue hypoxia occurs frequently during high-risk surgery in high-risk patients. We want to see if an algorithm aimed at optimizing intraoperative tissue oxygenation reduces perioperative complications as well as length of stay in the intensive care…
Our primary objective is to compare the short term (3 months follow-up) clinical and radiographic results of the Bledsoe Thruster Brace with the SofTec OA Brace in the management of patients with medial knee OA and a varus leg alignment.
Objective of the study is to test the effects of two different interventions during the nightshift on alertness and performance and on sleep quality and health complaints in general. The interventions are short exposure to light or taking a powernap…
To determine the safety and effectiveness of the PROMUS Element* Everolimus-Eluting Coronary Stent System (Boston Scientific Corporation [BSC], Natick, MA) for the treatment of patients with up to 2 de novo atherosclerotic lesions
The overall aim of the study is to evaluate the difference in speech performance of a new hands-free speech valve as compared to the currently most used (Atos) exhalation speech valve.