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A randomized, double-blind controlled trial on the effects of the mouthrinse containing edible mushroom (shiitake) extract on dental plaque acidogenicity and microbial composition

Main objective is to investigate if low molecular weight fraction of edible mushroom Shiitake extract possesses clinically relevant caries preventive properties

Phase 1b/2 Study to Assess the Safety and Efficacy of AMG 102 in Combination
with Mitoxantrone and Prednisone in Subjects with Previously Treated Castrate Resistant Prostate Cancer

The objective of the study (phase 2) is to evaluate the effectiveness of AMG 102 in combination with Mitoxantrone and Prednisone in previously treated subjects with castrate resistant prostate cancer.

Romantic love and serotonin

In the current study this hypothesis will be tested by examining whether blood serotonin levels, which are indicative of central serotonin levels, differ between infatuated and non-infatuated individuals. Furthermore, it will be investigated whether…

Cross-sectional cohort study to analyse the relation between advanced glycation end-products (AGEs) and diastolic function in patients with diabetes mellitus with and without chronic heart failure.

Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…

Cost-effectiveness of collaborative care for chronic medically ill patients with comorbid depressive disorder in the general hospital setting

The primary aim of the study is to test the effectiveness of a collaborative care model for major depressive disorder for patients with DM, CVD, COPD, and HIV in the general hospital outpatient setting. Secondary aim is to estimate the cost-…

What role do immune cells have in the development and persistence of Sjögren's syndrome?

This research project aims to investigate the interaction between systemic immune cells and cells from the glandular tissue of patients with Sjögren's syndrome and sicca syndrome. We hope to obtain more insight in the cause and persistence of…

DYANA Study - Dynamic Annuloplasty System with Activation for the Treatment of Mitral Regurgitation

To evaluate and compare complication and mortality rates tocurrent rates available for repairs with commercially availableannuloplasty rings. (0, 0+)

Traumatic and non-traumatic knee complaints in general practice: 6-year follow-up of the HONEUR knee cohort

The primary objective of this study is to determine the long-term clinical course in patients who consulted their general practitioner 6 years ago with a new episode of knee complaints. The secondary objectives of this study are to determine…

Effect of dietary proteins on blood pressure

The primary objective of the study is to demonstrate a difference in changes in fasting blood pressure and 24-hour ambulatory blood pressure after 4 weeks on a diet with a high protein content or a diet with a high carbohydrate content.Secondary…

Effects of INsulin dEtemiR and neutral protaminE hagedorn (nph) insulin on BRain glucOse metabolism: a study in persons with type 1 diabetes

The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…

A training program for people with dementia and their family caregivers:
A randomized controlled trial

One of the promising combined interventions is an intervention developed by Teri and colleagues. People with dementia receive an exercise program together with their caregivers. The caregivers are also trained in behaviour management techniques to…

Metabolic network activity and atrophy patterns in patients with parkinsonian disorders

Databases with multimodal brain imaging data (FDG-PET, VBM, DTI) will be created. From these data image features and network patterns will be extracted, to be used to create a supervised classification method for associating brain patterns to…

High and intermediate risk SPECT-CT optimization study

The primary objective is to compare whether results from fusion imaging of MSCT-CA and myocardial perfusion SPECT lead to similar or different therapeutic choices as compared to results from myocardial perfusion SPECT and invasive coronary…

Medication induced blood pressure reduction; assessment of cerebral perfusion and cognition in hypertensive elderly

To demonstrate that after a reduction in systolic blood pressure between 20 and 80mmHg within 3 months to reach a target of 140 mmHg, cerebral blood flow is not lower than prior to the start of treatment.

Cerebral control of social behaviour in social anxiety disorder

To assess differences in brain activation during the AA task in participants with SAD.

Safety and Efficacy of BL 5010 in Removal of Lesions in Patients with Seborrheic Keratosis

This study is being conducted to provide a preliminary assessment of whether BL-5010 sloughs off SK lesions and has an acceptable safety profile (including no or minimal dermal irritation following the application at the site of the SK lesion).…

Cannabis as a cause of psychosis: An ecogenetic study linking cannabis-induced dopamine response to psychotic mechanisms and experiences

The following research questions are formulated:A. Does exposure to cannabis (THC) result in an increased dopamine response in the striatum (as measured with PET)? And does cannabis use lead to an increase in psychotic experiences or symptoms?B. Do…

A multicenter, double-blind, randomized, placebo-controlled, parallel group, event-driven, Phase III study to assess the effects of ACT-064992 on morbidity and mortality in patients with symptomatic pulmonary arterial hypertension

Primary objective• To demonstrate that either dose of ACT-064992 prolongs the time to the first morbidity or mortality event in patients with symptomatic pulmonary arterial hypertension.Secondary objectives• To demonstrate that either dose of ACT-…

A Phase III, 3-Arm, Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Investigate the Impact of Diamyd® on the Progression of Diabetes in Patients Newly Diagnosed with Type 1 Diabetes Mellitus.

The primary objective is to evaluate the efficacy of i) a prime-and-boost regimen with 20 µg Diamyd and ii) a prime-and-boost regimen with 20 µg Diamyd, followed by 2 additional single doses with 20 µg Diamyd, compared to placebo with respect…

A Phase 2/3, Randomized, Double-Blind, Multicenter, Multinational, 4-Arm,
Controlled, Dose-Ranging Study to Evaluate Efficacy and Safety of Teplizumab
(MGA031), a Humanized, FcR Non-Binding, Anti-CD3 Monoclonal Antibody, in
Children and Adults with Recent-Onset Type 1 Diabetes Mellitus

Primary:The primary objective of this study is to assess, relative to placebo, the efficacy, tolerability, andsafety of teplizumab when administered according to 3 different teplizumab dosing regimens insubjects with recent-onset (onset within past…