No registrations found.
ID
Source
Brief title
Health condition
Parkinson's Disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
Probable/definite sleep bruxism and awake bruxism; temporomandibular disorders
Secondary outcome
Several variables will be evaluated: disease stage, disease severity, medication use, cognitive function, neuropsychiatric symptoms, quality of sleep, stimulant use (alcohol, smoking and drugs), reflux, dry mouth.
Background summary
Primary Objective: To investigate the prevalence of bruxism and temporomandibular disorders (TMD) in PD patients through objective measurements.
Secondary Objectives:
- To identify factors associated with a higher risk of developing the presence of TMD or bruxism.
- To investigate the salivary flow in patients with PD.
- To investigate whether the salivary flow, the pH, and the buffer capacity in patients with PD are
related to the severity of tooth wear and if this is different in patients with(out) bruxism.
- To investigate whether PD patients with bruxism differ in brain pathophysiology compared to PD
patients without bruxism.
Study objective
The null hypothesis will be that the prevalence of bruxism and TMD, in PD patients will be higher than in their peers without PD. Also, we hypothesized that factors as medication use, disease severity, psychosocial factors and lifestyle factors are associated.
Study design
1 (+one week)
Intervention
not applicable
M.C. Verhoeff
(020) 5980380
m.c.verhoeff@acta.nl
M.C. Verhoeff
(020) 5980380
m.c.verhoeff@acta.nl
Inclusion criteria
- Patients who visit the outpatient clinic for movement disorders of the VUmc hospital with (presumable) PD.
- Adults (>18 years old)
Exclusion criteria
- Children or adolescents (<18 years old)
- Patients with a pacemaker (only excluded for using GrindCare®)
- Patients without an available smartphone (only excluded for using the mobile application
BruxApp)
- Patients who do not fulfil the clinical diagnostic criteria for PD
- Patients with atypical parkinsonian syndromes
- Montreal Cognitive Assessment (MoCA) score < 21
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8307 |
| Other | METC VUmc : 2019.143 |