To compare gastrointestinal digestion (gastric emptying and postprandial amino acids dynamics) between two dairy-based drinks containing casein and matched on macronutrient composition but differing in mineral composition.
ID
Source
Brief title
Condition
- Gastrointestinal motility and defaecation conditions
Synonym
Health condition
Research involving
Sponsors and support
Intervention
- Food (substances)
Outcome measures
Primary outcome
1. Postprandial plasma amino-acid concentrations 2. Gastric emptying rate
Secondary outcome
1. Postprandial glucose and insulin levels 2. Gastric layer formation and other product instabilities if visible 3. Fullness, bloating, nausea ratings obtained after each MRI measurement
Background summary
Study objective
Study design
Intervention
Study burden and risks
may all cause minimal discomfort. These is no benefit to participation for the participants, the group is only related insofar as they are healthy males.
Age
Inclusion criteria
• Male • Age 18 – 55 y • Healthy • Normal-weight (BMI 18.5 – 25)
Exclusion criteria
• Cow milk allergy or intolerance (self-reported) • Lactose intolerance (self-reported) • Gastric disorders or regular gastric complaints, heart burn for example • Use of proton pump inhibitors or other medication which alters the normal functioning of the stomach, such as: o medical drug use that influences the GI tract’s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc. o Medical drug use that influence the GI tract’s microbiota: antibiotic use within 1 months prior to the pre-study screenings day • Use of recreational drugs within 1 month prior to the pre-study screenings day • Alcohol consumption of more than 14 glasses/week • Being vegan • Participating in other research • Smoking • Having given a blood donation in the past 2 months • Having a contra-indication to MRI scanning (including, but not limited to): ▪ Pacemakers and defibrillators ▪ Intraorbital or intraocular metallic fragments ▪ Ferromagnetic implants ▪ Claustrofobia • Not having a general practitioner or unwillingness to share unexpected findings with the gen-eral practitioner
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8959 |
| Other | METC Wageningen : 71177 |
| CCMO | NL71177.081.19 |
| OMON | NL-OMON49160 |