No registrations found.
ID
Source
Brief title
Health condition
End stage renal disease, allograft failure
Sponsors and support
Intervention
Outcome measures
Primary outcome
The one-year graft survival of a second kidney transplant compared to a first
kidney transplant.
Secondary outcome
1. The five- and ten-year graft survival of a second kidney transplantation
2. The one-year patient survival after a second kidney transplantation
Background summary
Kidney transplantation has become the most preferred form of treatment for kidney failure. Currently, around 1 million people in the United States are suffering from kidney failure. Annually, an approximate number of 15,000 kidney transplantations are performed in the United States. As a result of improvements in all aspects of kidney transplantation in the past few decades, the allograft survival has been increased. Unfortunately, in some cases a second transplantation is necessary. A second kidney transplantation could have a decreased allograft survival since this group has already been exposed to alloantigens and thereby has experienced loss of their first graft. Nevertheless, the success rates of second kidney transplantations after a first graft was lost (especially early after transplantation) is not completely known. We want to conduct a systematic review and meta-analysis to assess the graft survival of a second kidney transplantation compared to a first kidney transplantation in adults (> 18 years) We want to search PubMed for studies that examined the graft survival of a second kidney transplant in recipients > 18 years and complied our eligibility criteria. Our primary outcome is the one-year graft survival of a second kidney transplant compared to a first kidney transplant. Results are reported with an Odds Ratio (OR), using a random effects model from Cochrane Statistical Package Review Manager 5.3.
Study objective
The one-year graft survival of a second kidney transplant will be inferior to the one-year graft survival of a first kidney transplant.
Study design
1 year
5 years
Intervention
Systematic literature review using EMBASE, MEDLINE ALL Ovid, the Cochrane Central Register of Trials, Web of Science Core Collection and Google scholar.
Inclusion criteria
1. Patients of 18 years and older who recieved a second kidney transplant
2. Clinical trials, cohortstudies, retrospective studies, longitudinal studies and prospective studies.
3. English-language studies
Exclusion criteria
1. Case reports and conference reports.
2. Studies included preemptive kidney transplantation
3. Studies included nephrectomy
4. Studies comparing influences of immunosuppressants, HLA-matching, thrombosis, noncompliance or trauma-death donors
5. Studies that combine kidney transplantation with another organ transplantation
6. Studies who did not mention the one-year graft survival of the second kidney transplant
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8707 |
| Other | Erasmus MC - own investigation and funding : ErasmusMC220781 |