No registrations found.
ID
Source
Brief title
Health condition
Pheochromocytoma, paraganglioma, diagnosis, metanephrines
Sponsors and support
Intervention
Outcome measures
Primary outcome
The diagnostic accuracy (sensitivity and specificity) of salivary levels of metanephrines
Secondary outcome
1. To evaluate the self-reported anxiety levels in patients with a PCC/sPGL, in comparison with healthy subjects and germline mutation carriers without elevated plasma metanephrines levels and to correlate the anxiety levels to the plasma metanephrines levels
2. To determine whether position (sitting vs. supine position) influences salivary metanephrines levels.
3. To establish a reference set for plasma and salivary metanephrines in supine position after 30 minutes of rest
4. To compare the ROC curves for the PCC/sPGL patients with the ROC curve of salivary and plasma metanephrines of asymptomatic germline mutation carriers.
Study objective
1. Measurement of salivary metanephrines is just as accurate as plasma metanephrines in detecting a pheochromocytoma or sympathetic paraganglioma.
2. Anxiety levels are elevated in patients with a pheochromocytoma or sympathetic paraganglioma
Study design
Not applicable
Intervention
Collecting saliva and collecting 20 ml blood.
Filling out a anxiety questionnaire
[default]
The Netherlands
[default]
The Netherlands
Inclusion criteria
Patients (age > 18 years) with a pheochromocytoma or sympathetic paraganglioma, with elevated plasma metanephrines AND
Germline mutation carriers without elevated plasma metanephrines AND
Healthy subjects
Exclusion criteria
The need to use medication known to influence plasma metanephrines concentration: tricyclic antidepressants, phenoxybenzamine, MAO-inhibitors, sympathomimetics, cocaine, methyldopa
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4962 |
| NTR-old | NTR5066 |
| CCMO | NL50957.042.14 |
| OMON | NL-OMON43844 |