No registrations found.
ID
Source
Brief title
Health condition
COVID-19
Sponsors and support
Intervention
Outcome measures
Primary outcome
Difference in sensitivity of blood plasma SAA, CRP , ferritin and PCT levels on day 1, day 3, day 5 and day 7 of hospital stay in patients with severe versus non-severe COVID-19 disease course.
Secondary outcome
• Specificity, positive and negative predictive values, positive and negative likelihood ratios SAA versus CRP, ferritin and PCT.
• Clinical course of COVID-19 including classification of COVID-19 severity according to the WHO criteria (Clinical management of COVID-19 (who.int)).
• Disease outcome at time of hospital discharge (or death).
Background summary
The goal of this study is to investigate recent claims from Chinese studies that serum amyloid A (SAA) is a superior prognostic inflammatory marker in COVID-19 when compared to CRP, ferritin and PCT on day 1, day 3, day 5 and day 7 of hospital admission.
Study objective
SAA is superior to CRP, ferritin and procalcitonin as prognostic inflammatory marker in COVID-19
Study design
d1, d3, d5, d7
Intervention
None
Inclusion criteria
18 jaar or older;
hospitalised for (suspicion of) COVID-19;
written informed consent for those subjects admitted to the non-ICU clinical COVID-19 ward.
Exclusion criteria
Subjects undergoing experimental interventions will be excluded.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9082 |
| Other | MEC-U : not yet available |