IgG4-associated cholangitis mimicks perihilar cholangiocarcinoma, resulying in patients being resected for benign disease
ID
Source
Health condition
IgG4-associated cholangitis
Sponsors and support
Intervention
Outcome measures
Primary outcome
Incidence of IgG4-associated cholangitis in patients resected for presumed PHC
Secondary outcome
Evaluation of active disease with sIgG4 and qPCR test for IgG4/IgG mRNA ratio
Background summary
Our aim is to assess the incidence of Immunoglobulin G4-associated cholangitis (IAC) in patients resected for presumed perihilar cholangiocarcinoma (PHC). All patients that underwent resection for presumed PHC at our institution between 1984 and 2015 were included. Benign histological specimens were re-evaluated by a pathologist and scored according to the international pathological consensus criteria for IgG4-RD. Patients with benign disease who were still alive were re-evaluated to assess IgG4 serum levels and IgG4/IgG RNA ratio to detect activity of IAC.
Study objective
IgG4-associated cholangitis mimicks perihilar cholangiocarcinoma, resulying in patients being resected for benign disease
Study design
-re-evaluation resection specimens
-clinical re-evaluation symptoms and serummarkers
Intervention
None
Inclusion criteria
Resection for presumed perihilar cholangiocarcinoma
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6287 |
| NTR-old | NTR6461 |
| CCMO | NL58029.018.16 |
| OMON | NL-OMON42948 |