No registrations found.
ID
Source
Brief title
Health condition
Rheumatoid arthritis,
Cardiovascular disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the results from the handscan measurement, arterial stiffness as measured with pulse wave velocity and augmentation index, DAS28 and the ultrasound assessment of the hand joints at all time points.
Secondary outcome
N/A
Background summary
In the last decade, treatment advances in rheumatoid arthritis (RA) have resulted in a tremendous improvement in therapeutic outcomes. One of these advances is treat-to-target therapy. However, a valid detection instrument for disease activity is still necessary. Currently a composite measure called Disease Activity Score (DAS28) is used for this. However, a new imaging device called handscan might be an appropriate disease activity detection instrument as well. Measurements with the handscan are fast and probably less investigator-dependent. The handscan uses hemodynamics of the smaller vessels to measure inflammation in the hand joints and therefore a correlation between the handscan measurement and arterial stiffness, as assessed with pulse wave velocity, might be present.
The objectives of this study are to investigate the correlation of the handscan measurement with DAS28 and ultrasound measurement of the hands and to investigate the responsiveness to therapy of the handscan device. Also the correlation between the handscan and arterial stiffness will be investigated.
Study objective
N/A
Study design
Baseline, 1 month and 4 months.
Intervention
N/A
Inclusion criteria
- 18 years or older
- Active rheumatoid arthritis in hands or wrists, defined as ≥ 2 swollen hand joints (IP, PIPs and/or MCPs) or ≥ 1 swollen wrist joints
- Starting with TNF-inhibiting therapy (first- or second line)
Exclusion criteria
- Surgery in wrist or hand in the preceding 3 months
- Other active concomitant musculoskeletal disease
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7257 |
| NTR-old | NTR7479 |
| CCMO | NL64183.048.17 |
| OMON | NL-OMON48787 |