No registrations found.
ID
Source
Brief title
Health condition
Cardiac arrest (hartstilstand)
Resuscitation (reanimatie)
Postanoxic coma (postanoxisch coma)
Helium (helium)
Sponsors and support
Intervention
Outcome measures
Primary outcome
Occurence of major adverse events (death, inability to effectivly ventilate using helium/oxygen).
Secondary outcome
1. Arterial blood gas;
2. Ventilator settings;
3. Creatine Kinase;
4. Creatine Kinase MB;
5. Troponin-T;
6. Neuro Specific Enolase;
7. Glassgow Outcome Score;
8. Mortality;
9. Duration of mechanical ventilation;
10. Length of stay on ICU.
Background summary
N/A
Study objective
Helium can be safely used in patients admitted to the ICU after resuscitation for out-of-hospital cardiac arrest.
Study design
1. ABG at 0, 1, 2, 3, 4, 5 and 6 hours;
2. Ventilator settings at 0, 1, 2, 3, 4, 5 and 6 hours;
3. CK at 0, 6, 12, 18, 24 and 48 hours;
4. CK-MB at 0, 6, 12, 18, 24 and 48 hours;
5. Troponin-T at 0, 6, 12, 18, 24 and 48 hours;
6. NSE at 24 and 48 hours;
7. Glassgow Outcome Score at 30 days;
8. Mortality at 30 days.
Intervention
Ventilation with helium/oxygen (50%/50%) during the first 3 hours after inclusion.
Daniel Brevoord
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
d.brevoord@amc.nl
Daniel Brevoord
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
d.brevoord@amc.nl
Inclusion criteria
1. Admission to the ICU with postanoxic coma after OHCA;
2. First registered rhythm VF/VT;
3. Witnessed arrest;
4. Return of spontaneous circulation within 30 minutes;
5. Induced mild hypothermia;
6. Ability to start study medication within 6 hours.
Exclusion criteria
1. Life expectancy < 6 months prior to arrest;
2. Neurological disosrder prior to arrest;
3. Severly disabled prior to arrest;
4. Pregnancy;
5. Pulmonary illness, requiring ventilation with >50% FiO2 and > 10 cmH2O PEEP.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2133 |
| NTR-old | NTR2257 |
| Other | METC AMC / CCMO : MEC 09/333 / NL 30466.018.09 ; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |