No registrations found.
ID
Source
Health condition
Pulmonary embolism
longembolie
Sponsors and support
Intervention
Outcome measures
Primary outcome
The diagnostic accuracy of the perfsuion scan criteria in comparison to CT scan.
Secondary outcome
1. Positive predictive value;
2. Negative predictive value;
3. Proportion of diagnostic Q scans.
Background summary
CT scanning has become a standard test in the diagnostic workup of patients with suspected PE. However, young patients, especially women, likely have an increased risk of (breast) cancer due to radiation exposure with CT scanning. Perfusion scanning has a much lower radiation exposure burden. Therefore, in this study, the accuracy of the PISAPED criteria for the evaluation of perfusion scans for the diagnosis of PE is studied in comparison to CT scan. Patients aged < or = 50 years old with suspected PE who need CT scanning according to current diagnostic work up criteria (i.e. either a 'likely' or 'high' clinical probability or an abnormal D-dimer test) will undergo perfusion scintigraphy. Q scan and CT scan will be compared for the absence or presence of PE.
Study objective
To study the accuracy of the PISAPED perfusion scan criteria compared with CT scanning in patients aged < or = 50 years with suspected pulmonary embolism, a likley or high clinical probability and/or an abnormal D-dimer.
Study design
Moment of diagnostic tests to rule out or confirm PE.
Intervention
Perfusion scintigraphy, chest X-ray and CT scan in patients with likely or high clinical probablity and/or an abnormal D-dimer with suspected pulmonary embolism.
Inclusion criteria
In- or outpatients aged < or = 50 years, with clinically suspected pulmonary embolism, who have a 'likely' (Wells score) or 'high' (revised Geneva score) clinical probability for pulmonary embolism and/or an abnormal D-dimer test and in hwom a cT scan will be made.
Exclusion criteria
1. Age <18 years or > 50 years;
2. Pregnancy;
3 (Low molecular weight) heparin for longer than 48 hours prior to eligibility assessment;
4. Inability to perfom a perfusion scan withing 24 hrs after CT scan;
5. Participation in a therapeutic study for pulmonary embolism is not an exclusion criterion.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2087 |
| NTR-old | NTR2203 |
| Other | MEC LUMC - substudy : P07.266 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |