Critical illness, along with the lack of zeitgebers on the PICU environment, and iatrogenic influences like medication and procedures, results in disturbed circadian rhythms in critically ill children, which is important for their recovery.
ID
Source
Brief title
Condition
- Exposures, chemical injuries and poisoning
Health condition
Critical illness in general
Research involving
Sponsors and support
Intervention
- Other intervention
Outcome measures
Primary outcome
To describe the distributions of rhythmic parameters in the paediatric ICU and their evolution during PICU stay.
Secondary outcome
1. To identify the correlations between different circadian rhythm parameters. 2. To construct a robust combined measure of circadian rhythmicity from these parameters. 3. To assess the accuracy of combinations of vital signs in determining underlying circadian rhythm with the constructed measure mentioned in secondary objective 2 as a reference. 4. To determine the association between circadian rhythms in relation with both patient and disease characteristics on one hand and outcome on the other.
Background summary
Many processes in the human body show variations during every 24 hours, which is called the circadian rhythm. This rhythm is vital for normal homeostasis. In critically-ill adults circadian disturbances have been associated with increased sepsis severity and length of ICU stay, whereas in children little research has been performed. The intensive care unit necessitates a multi-faceted approach in the study of circadian rhythms, although this approach has not been used yet. This study will assess the status of the circadian rhythm of critically-ill children in biomarkers, vital signs, sleep, and gene expression, along with its role in critical illness.
Study objective
Critical illness, along with the lack of zeitgebers on the PICU environment, and iatrogenic influences like medication and procedures, results in disturbed circadian rhythms in critically ill children, which is important for their recovery.
Study design
PICU admission
Intervention
None
Age
Inclusion criteria
- All children with an expected PICU-stay of at least two days.
Exclusion criteria
- Preterm, i.e. postconceptional age of <37 weeks, on admission - Syndrome associated with severe mental retardation, except for trisomy 21 - Hydrocortison use in the 3 days prior to admission - Melatonin use within 24 hours prior to admission - Transfer from another PICU or NICU - Weight < 2.0 kg - Expected not to receive arterial line during study period - Previously included in this Critical Clock study
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8533 |
| CCMO | NL72597.078.20 |
| OMON | NL-OMON49654 |