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ID
Source
Brief title
Health condition
The participants to this study are healthy adults.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cognitive measures: Number of words remembered (15 word test), variable representing the Simon effect for inhibition (Simon task), completion time (TMT).
Imaging measures as derived from MRI scans: Whole brain grey matter volume, cortical thickness in the superior frontal gyrus, FA of the prefrontal cortex
Secondary outcome
Main study parameters of cognitive performance consist of the default outcome measures of each cognitive task. Regarding the MRI scans we derive volumetric data of grey matter, white matter and cerebral spinal fluid,(mean) cortical thickness, percentage of white matter hyperintensities in relation to brain volume, and DTI scalar values (FA, MD, AD and RD). Standardized change scores of these measures will be calculated.Further more information on reduction of working hours and possible retirement will be taken into consideration.
Background summary
This study aims at gaining a broad picture of age-related changes in brain structure and cognitive functioning in a group of older adults by using a longitudinal within‐subjects design. The majority of previous studies examining the effects of age on brain and cognition have used cross-sectional designs, that is, comparing groups of young- and older adults in order to examine the effects of age. The proposed study provides an effort to overcome the problems associated to cross-sectional research by examining the dynamics of age-related changes from a longitudinal perspective. Furthermore, structural and functional changes over time will be associated to major life events, such as reduction in working time and retirement.
Study objective
We expect changes in each of the three tasks, with less words remembered (15 word test), a larger Simon effect (Simon task) and slower performance (TMT) in the repeated assessment compared to the first assessment. We also expect changes in each of the three main structural measures: Whole brain grey matter volume (smaller over time), cortical thickness in the superior frontal gyrus (thinner over time), and FA of the prefrontal cortex (lower over time).
Study design
One time point, scheduled approximately 2 years after participating in the study 'Age and performance: the relation between brain structure and cognition'
Intervention
not applicable
Inclusion criteria
- Having participated in the study ‘Age and performance: the relation between brain structure and cognition’.
- Right-handed
- Normal (or corrected to normal) vision
Exclusion criteria
Not matching any of the inclusion criteria, as well as matching any criterion in the MRI exclusion list, including, but not limited to, claustrophobia, infarctions, epilepsy or family history of epilepsy, presence of metal inside the body, presence of electric/electronic devices inside the body (pacemakers, etc.), and presence of intracardial lines. We will exclude users of non-removable dentures, psychoactive medication, including antidepressants, anxiolytic, and anti-epileptic drugs, as well as cannabis, XTC or other recreational drugs.
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL7637 |
| Other | METc Groningen : METc 2019.160 |