No registrations found.
ID
Source
Brief title
Health condition
Hemophilia patients
Vascular calcification
Ankle brachial index
Sponsors and support
Intervention
Outcome measures
Primary outcome
Ankel brachial index
Toe brachial index
Secondary outcome
- Blood pressure, weight, height, waist circumference
- Data related to cardiovascular risk factors will be obtained by a standardised questionnaire.
- Severity of haemophilia, bleeding events.
-Total cholesterol, LDL-, and HDL- cholesterol, triglycerides, glucose, HbA1c, creatinine, alkaline phosphatase, calcium, phosphate, albumin.
Study objective
In hemophilia patients arterial hypertension is more common than in de general population. The cause of this increased prevalence is unknown. Recent studies on atherosclerosis in hemophilia focused on intima lesions. However, arterial calcification may affect the media as well. Medial arterial calcification (MAC) leads to concentric media thickening and stiffening of the arterial wall. Since arterial stiffness is an important contributor to arterial hypertension, MAC and consequently arterial stiffness may be more prevalent in hemophiliacs, and this may explain the high rate of systolic hypertension. MAC can be detected by measurement of the ankle brachial index. There are no reports on MAC in hemophilia.
Study design
single visit
Intervention
Single measurement of ankel brachial index and toe brachial index.
Hilde Hop
Hanzeplein 1
Groningen 9713 GZ
The Netherlands
Tel: +31503612943
Mail: h.hop@umcg.nl
Hilde Hop
Hanzeplein 1
Groningen 9713 GZ
The Netherlands
Tel: +31503612943
Mail: h.hop@umcg.nl
Inclusion criteria
- Hemophilia A or B
- Males, adults
-Written informed consent for study participation
Exclusion criteria
- History of peripheral artery occlusive disease.
- History of ESRD , defined as eGFR < 60 ml/ min, calculated according to the Modiļ¬cation of Diet in Renal Disease formula.
- History of Diabetes Mellitus.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5145 |
| NTR-old | NTR5284 |
| CCMO | NL51599.042.14 |
| OMON | NL-OMON44851 |