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ID
Source
Brief title
Health condition
Hip fracture
Sponsors and support
Intervention
Outcome measures
Primary outcome
Bone protein synthesis rates in the femoral shaft and femoral head tissue, expressed in FSR (%/h)
Secondary outcome
The secondary outcome parameters are tissue-specific protein synthesis rates in femoral bone, femoral head cartilage, hip synovium, and m. gluteus maximus, expressed in FSR (%/h).
Background summary
Skeletal muscle plasticity is defined by a dynamic balance between protein synthesis and protein breakdown rates. Recently, we have shown basal protein synthesis rates in various musculoskeletal tissues of the knee joint, including bone, cartilage, and tendon tissue. Interestingly, most of these tissues possess protein synthesis rates within the same range of skeletal muscle protein synthesis rates. However, it is not known whether the protein synthesis rates of bone tissue change after a traumatic event (i.e. bone fracture). In older adults, hip fractures are one of the most common fractures that require surgical intervention. After a hip fracture, the vitality of the femoral head is often reduced. It is not known whether osteonecrosis of the femoral head happens due to reduced protein synthesis or extensive breakdown. Therefore, this project will apply the stable isotope methodology to measure tissue-specific protein synthesis rates in fractured femoral bone.
Study objective
We expect the protein synthesis rate in (avascular) femoral bone proximal to the fracture to be lower when compared to healthy femoral bone.
Study design
2.5h before start of surgery untill the end of the surgical procedures.
Intervention
None
Floris Hendriks
0655522347
f.hendriks@maastrichtuniversity.nl
Floris Hendriks
0655522347
f.hendriks@maastrichtuniversity.nl
Inclusion criteria
1) Written informed consent;
2) Recent (<24 h before admission to the hospital) femoral bone fracture requiring hip replacement surgery;
3) Admitted to MUMC+ to receive a femoral head-neck prosthesis or total hip replacement.
Exclusion criteria
1) Physical restlessness due to delirium;
2) Rheumatoid arthritis;
3) Chemotherapy or radiotherapy;
4) (Multiple) Myeloma or other primary cancer tumor with possible bone metastasis;)5) Collagen disorders, e.g. Marfan and Ehler-Danlos;
6) Any other medical condition that may interfere with the safety of the subjects or the outcome parameters, in the investigators judgement;
7) Investigator’s uncertainty about the willingness or ability of the subject to comply with the protocol instructions;
8) Participation in any other studies involving investigational or marketed products concomitantly to entry into the study.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL9036 |
| Other | METC AzM/UM : METC 20-082 |