No registrations found.
ID
Source
Brief title
Intervention
Background summary
10 healthy volunteers and 10 patients will be subjected to a Buspiron-Challange-Test during functional MRI. During the morning of the test blood samples will be collected (6 times 5 ml) to assess the concentration prolactin, ACTH, GH and cortisol. Furthermore, dyspeptic symptoms will be scored during the test.
Intervention
Single dose of Buspiron (30 mg).
P.O. Box 22660
G.E.E. Boeckxstaens
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5667375
g.e.boeckxstaens@amc.uva.nl
P.O. Box 22660
G.E.E. Boeckxstaens
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5667375
g.e.boeckxstaens@amc.uva.nl
Inclusion criteria
Healthy volunteers: absence of gastrointestinal symptoms, Nepean Dyspepsia Index (NDI) score < 5, > 18 years of age.
Patients: Nepean Dyspepsia Index (NDI) score >25, > 18 years of age.
Exclusion criteria
Healthy volunteers: use of drugs that affect gastrointestinal motility (antidepressants, opiates, NSAID’s, calcium-blockers, nitrates), previous abdominal surgery, epilepsy, severe liver of renal insufficience, depression, claustrophobia, metal
implants, not be able to lie down for 15 minutes.
Patients: use of drugs that affect gastrointestinal motility (antidepressants, opiates, NSAID’s, calcium-blockers, nitrates), IBS, previous abdominal surgery, epilepsy, severe liver of renal insufficience, depression, claustrophobia, metal
implants, not be able to lie down for 15 minutes.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL26 |
| NTR-old | NTR48 |
| Other | : N/A |
| ISRCTN | NO ISRCTN (cancelled) |