REE will be assessed using indirect calorimetry. Oxygen consumption (VO₂) and carbon dioxide production (VCO₂) will be measured. The respiratory quotient (RQ) will be derived from VO₂ and VCO₂. Body composition will be…
ID
Source
Brief title
Condition
- Neoplasm related morbidities
Health condition
Cancer
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
REE will be assessed using indirect calorimetry. Oxygen consumption (VO₂) and carbon dioxide production (VCO₂) will be measured. The respiratory quotient (RQ) will be derived from VO₂ and VCO₂.
Secondary outcome
Body composition will be determined by bioelectrical impedance analyses (BIA). Fat mass (FM) and fat free mass (FFM) will be derived. Subsequently, the percentage of FM (%FM) and FFM (%FFM) will be calculated. Physical activity will be assessed using an Actigraph. The intensity of physical activity (sedentary, light, moderate, and vigorous physical activity), steps per day and metabolic equivalents (METs) of physical activity will be derived. Dietary intake will be explored using three-day food records. A blood sample will be taken for cytokine analysis.
Background summary
healthy body weight. Components of total energy expenditure (TEE) include resting energy
expenditure (REE), physical activity and diet induced thermogenesis, representing
respectively 50-70%, 15-40% and 10% of TEE in children and adolescents. Since cancer and
its treatment can influence all of these components, estimation of energy requirement in
patients with cancer is challenging. Longitudinal data regarding REE in children with cancer
throughout treatment are limited and showed contradictory results.
Study objective
dioxide production (VCO₂) will be measured. The respiratory quotient (RQ) will be derived
from VO₂ and VCO₂.
Body composition will be determined by bioelectrical impedance analyses (BIA). Fat mass
(FM) and fat free mass (FFM) will be derived. Subsequently, the percentage of FM (%FM) and
FFM (%FFM) will be calculated.
Physical activity will be assessed using an Actigraph. The intensity of physical activity
(sedentary, light, moderate, and vigorous physical activity), steps per day and metabolic
equivalents (METs) of physical activity will be derived.
Dietary intake will be explored using three-day food records.
A blood sample will be taken for cytokine analysis.
Study design
Study burden and risks
Denise Froon-Torenstra
Heidelberglaan 25
Utrecht 3584 CS
Nederland
0650006465
d.froon@prinsesmaximacentrum.nl
Denise Froon-Torenstra
Heidelberglaan 25
Utrecht 3584 CS
Nederland
0650006465
d.froon@prinsesmaximacentrum.nl
Age
Inclusion criteria
-Diagnosed with cancer -Treated with chemotherapy -Between 4-18 years old at the start of treatment -Ability to comprehend Dutch (both reading and writing)
Exclusion criteria
-Prior diagnosis of cancer -Having oxygen delivery -Inability to lay still for 20 minutes -Inability of completing an overnight fast prior to the measurement -Having an electric implant, such as a pacemaker -Having a biosensor, such as a glucose meter
Design
Recruitment
IPD sharing statement
Huispostnr D01.343
Postbus 85500
3508 GA Utrecht
088 755 6376
metc@umcutrecht.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7657 |
| Other | METC UMCU : METC nnb |