No registrations found.
ID
Source
Brief title
Health condition
rotator cuff degeneration
rotator cuff tears
Sponsors and support
Intervention
Outcome measures
Primary outcome
RNA profiling difference between subscapular and deltoid muscles and its correlation to magnetic resoncace imaging
Secondary outcome
cell proliferation
cell apoptosis
mitochondrial activity
cell fusion
cell senescence
Constant score
Range of motion
Muscle Strength
DASH
WORC
MR features including:
- fatty infiltration
- cross sectional surface area
Study objective
Age associated molecullar processess are involved in rotator cuff degeneration and the presence of rotator cuff tears
Study design
only at baseline/during surgery.
Intervention
biopsies of subscapular muscle and deltoid muscle
Postbus 9600
R.G.H.H. Nelissen
Leiden 2300 RC
The Netherlands
+31 (0)71 5269111
R.G.H.H.Nelissen@lumc.nl
Postbus 9600
R.G.H.H. Nelissen
Leiden 2300 RC
The Netherlands
+31 (0)71 5269111
R.G.H.H.Nelissen@lumc.nl
Inclusion criteria
MRI proven shoulder pathology for which shoulder surgery is needed.
Exclusion criteria
- Age < 18 and > 80 years
- No informed consent
- Comorbidity: neurological disorders (stroke, M. Parkinson, dementia, muscle
disease), rheumatoid arthritis, polymyalgia rheumatic, heart failure, COPD
(Gold III-IV), chronic pain syndrome (fibromyalgia, complex regional pain
syndrome etc)
- Metabolic diseases (e.g. insuline dependent DM)
- Cancer
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4584 |
| NTR-old | NTR4725 |
| Other | 44516 CCMO : P13.093 METC Leiden |