No registrations found.
ID
Source
Brief title
Health condition
The study population exists of major, non-cardiac surgery patients, who are expected to need > 3 units of red blood cell transfusions.
Sponsors and support
<br><br>
2. Sanquin Blood supply.
Intervention
Outcome measures
Primary outcome
Postoperative:
1. In-hospital mortality;
2. Duration of intensive care stay.
Secondary outcome
1. Postoperative multi organ failure;
2. Postoperative infections;
3. Length of hospital stay;
4. Costs/benefits of universal leukocyte depletion for the Dutch health care;
5. Role of perioperative medication;
Follow up
1. Long term survival;
2. Cancer recurrence in GI patients;
3. Predictive role of cytokines and related genes.
Background summary
The aim of the study is to compare postoperative complications in patients undergoing major surgery who received non-filtered or filtered red blood cell transfusions.
No significant differences were found in mortality (odds ratio for filtered v non-filtered 0.80, 95% confidence interval 0.53 to 1.21) and in mean stay in intensive care (- 0.4 day, - 1.6 to 0.6 day). In the filtered group the mean length of hospital stay was 2.4 days shorter (- 4.8 to 0.0 day; P = 0.050) and the incidence of multi-organ failure was 30% lower (odds ratio 0.70, 0.49 to 1.00; P = 0.050).
There were no differences in rates of infection (0.98, 0.73 to 1.32).
Conclusion:
The use of filtered transfusions in some types of major surgery may reduce the length of hospital stay and the incidence of postoperative multi-organ failure.
Study objective
Does removal of allogeneic white blood cells by filtration reduce postoperative complications?
Study design
N/A
Intervention
Transfusions of filtered red blood cell concentrates vs. transfusion of stored buffy coat depleted red blood cell concentrates.
P.O. Box 2184
J.A. Hilten, van
Leiden 2310 CD
The Netherlands
+31 (0)71 5685060
Joost.vanhilten@bloodrtd.nl
P.O. Box 2184
J.A. Hilten, van
Leiden 2310 CD
The Netherlands
+31 (0)71 5685060
Joost.vanhilten@bloodrtd.nl
Inclusion criteria
Acute aneurysm-, elective aneurysm-, orthopaedic- and large gastro-intestinal surgery patients.
Exclusion criteria
1. Under 18 years of age;
2. Transfusions received within 3 months prior to inclusion;
3. Pre existing medical indication for filtered red blood cell transfusions.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL271 |
| NTR-old | NTR309 |
| Other | : N/A |
| ISRCTN | ISRCTN48093674 |
Summary results
2. Ned Tijdschrift voor Hematologie 2005;
2:140-7