No registrations found.
ID
Source
Brief title
Health condition
Preeclampsia, cardiovascular disease, renal function, hemodynamics
Pre-eclampsie, hart- en vaatziekten, renale functie, hemodynamiek
Sponsors and support
Intervention
Outcome measures
Primary outcome
Renal vascular resistance.
Secondary outcome
Glomerular filtration rate, total peripheral vascular resistance, blood pressure, plasma volume, arterial and venous compliance and cardiovascular morbidity.
Background summary
Preeclampsia is associated with an increased risk on the development of cardiovascular and renal disease. It seems that similar risk factors are both predictive for preeclampsia and cardiovascular disease. We hypothise that women with a history of preeclampsia have accelerated vascular aging in comparison with controls. Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls. This is a longitudinal case-control study in which 20 formerly preeclamptic women and 10 controls will be included. Those women are recruited from a previous study performed in the period of 1996-1999. The same measurements, including blood pressure, PAH/inulin clearance, plasmavolume, arterial/venous compliance and echocardiography, will be performed.
Study objective
We hypothise that women with a history of preeclampsia have accelerated vascular aging in comparison with control women with uncomplicated pregnancies.
Study design
One day.
Intervention
None; observational case-control study.
Secr. Obstetrie/gynaecologie
Postbus 5800
T. Ekhart
Maastricht 6202 AZ
The Netherlands
+31 (0)43-3882101
T.Ekhart@og.unimaas.nl
Secr. Obstetrie/gynaecologie
Postbus 5800
T. Ekhart
Maastricht 6202 AZ
The Netherlands
+31 (0)43-3882101
T.Ekhart@og.unimaas.nl
Inclusion criteria
Participation in previous study period 1996-1999. Women with a history of preeclampsia and/or HELLP syndrome. Control women with uncomlicated pregnancies. Previous research within 3 years after pregnancy.
Exclusion criteria
Pre-existent hypertension.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1567 |
| NTR-old | NTR1647 |
| Other | MEC : 08-2-130 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |