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ID
Source
Brief title
Health condition
free fatty acid release
vrije vetzuur afgifte
Sponsors and support
P.O. Box 22660
1100 DD
Amsterdam
The Netherlands
+31 (0)20 5669111
Intervention
Outcome measures
Primary outcome
- Percent and/or absolute changes in nocturnal FFA levels with or without â-blockage.
Secondary outcome
- Difference in nocturnal FFA levels between lean and obese subjects
Background summary
It has been convincingly demonstrated that free fatty acids (FFA) play a key role in the induction of obesity-induced insulin resistance. The higher plasma levels of FFA originate from adipocytes which show higher rates of lipolysis in insulin stimulated states, i.e. insulin resistance of adipose tissue. The release of FFA is pulsatile and show a circadian rhythm and is thereby in part controlled by the central nervous system. Whether this pulsatility or rhythm is disturbed in insulin resistant subjects is not known. In a dog model FFA levels can be lowered by blocking the â-receptor present on the adipocyt, thereby decreasing the influence of the central nervous system on FFA release. In this study we aim to translate these findings to obese insulin resistant and lean insulin sensitive humans.
Study objective
Nocturnal FFA levels are higher in obese insulin resistant subjects and are less sensitive to the FFA lowering effects of a â-receptor blocker.
Study design
N/A
Intervention
Propranolol infusion
Department of Endocrinology and Metabolism <br>
P.O. Box 22660<br> 1100 DD
B.A.M. Weijer, de
Meibergdreef 9 (F5-177)
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666849
B.A.deWeijer@amc.uva.nl
Department of Endocrinology and Metabolism <br>
P.O. Box 22660<br> 1100 DD
B.A.M. Weijer, de
Meibergdreef 9 (F5-177)
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666849
B.A.deWeijer@amc.uva.nl
Inclusion criteria
1. Male obese subjects (BMI > 30 kg/m2) and healthy lean controls (BMI 20 > 25 kg/m2)
2. Age 20 – 50 years
3. Stable weight 3 months prior to study inclusion
4. Caucasian
5. Written informed consent
Exclusion criteria
1. Any chronic medical condition or use of any medication
2. Asthma and bronchospastic COPD
3. Tobacco use
4. Alcohol abuse (>3/day)
5. Frequent intensive exercise (>2 week)
6. Familial lipid disorders, renal insufficiency (creatinine > 150 umol/L) , elevated liver enzymes (> 2 times), hypertension
7. Hypotension (BP < 100/60 mmHg), bradycardia (HR < 60min)
8. Unwilling or unable to provide informed consent
9. First degree family members with diabetes
10. Abnormal day/night rhythm (shiftworkers etc)
11. Blood donation in the past three months
Design
Recruitment
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL1481 |
| NTR-old | NTR1549 |
| Other | : 08/282 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |