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ID
Source
Brief title
Health condition
Muscle metabolism
Protein
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary study parameter is myofibrillar protein synthesis rate.
Secondary outcome
Secondary endpoints will be plasma amino acid concentrations, glucose, and insulin concentrations.
Background summary
Skeletal muscle mass maintenance is regulated by two main anabolic stimuli, food intake and physical activity. Dietary protein intake directly stimulates muscle protein synthesis rates and inhibits muscle protein breakdown. Therefore, the post-prandial muscle protein synthetic response to feeding plays a key regulatory role in skeletal muscle mass maintenance.
The capacity of dietary protein to stimulate post-prandial muscle protein accretion varies between protein sources. More than half of the total amount of dietary protein that is consumed by humans worldwide is of plant origin, with plant based proteins providing up to 80% of dietary protein consumed in less developed regions. Overall it is assumed that plant based proteins are less potent in stimulating post-prandial muscle protein synthesis. However, the anabolic properties of plant based protein sources have hardly been assessed. Therefore, this project will investigate the anabolic properties of plant based proteins.
Study objective
It is hypothesized that the ingestion of plant based proteins will result in a similar muscle protein synthetic response compared to animal based proteins.
Study design
Blood and muscle samples will be collected at regular time intervals.
Intervention
Subjects will consume 30 g of protein in the form of a beverage.
Philippe Pinckaers
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
0031 43 388 2215
philippe.pinckaers@maastrichtuniversity.nl
Philippe Pinckaers
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
0031 43 388 2215
philippe.pinckaers@maastrichtuniversity.nl
Inclusion criteria
- Male
- Aged 18-35 y inclusive
- BMI 18.5 – 27.5 inclusive
- Healthy recreationally active
Exclusion criteria
- Females
- Wheat allergy
- Celiac disease
- Allergies to milk proteins
- Lactose intolerance
- Smoking
- Diagnosed diabetes
- Diagnosed metabolic or intestinal disorders
- A history of neuromuscular problems
- Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- Participation in structured resistance exercise program
- Previous participation in a 13C amino acid tracer study within the last 1 year
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6364 |
| NTR-old | NTR6548 |
| CCMO | NL60500.068.17 |
| OMON | NL-OMON50096 |