No registrations found.
ID
Source
Brief title
Health condition
opioid-induced respiratory depression
Sponsors and support
Intervention
Outcome measures
Primary outcome
Respiratory measurements
Secondary outcome
Pharmacokinetics, side effects
Study objective
We hypothesize that TRH effectively antagonize opioid-induced respiratory depression
Study design
Blood samples (pre-set time points), respiratory measurements, ECG, heart rate, oxygen saturation and blood pressure
Intervention
TRH or placebo (intravenously)
Albinusdreef 2
M. Velzen, van
Leiden 2333 ZA
The Netherlands
+31 (0)71 5262301
m.van_velzen@lumc.nl
Albinusdreef 2
M. Velzen, van
Leiden 2333 ZA
The Netherlands
+31 (0)71 5262301
m.van_velzen@lumc.nl
Inclusion criteria
- Healthy male or female volunteers;
- Age: 18 - 40 years;
- Body mass index < 30 kg/m2;
- Able to give informed consent.
Exclusion criteria
- Known or suspected neuromuscular or a (family) history of any neuromuscular disease;
- A history of allergic reaction to food or medication including study medication;
- Any current or previous medical (including high blood pressure), neurological or psychiatric illness (including a history of anxiety);
- Alcohol abuse (> 21 units/week);
- Illicit drug use in the past 30 days before inclusion;
- Pregnancy or lactation;
- Participation in any medical or drug trial in the month prior to the current study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6966 |
| NTR-old | NTR7154 |
| Other | : P18.005 |