Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
ID
Source
Brief title
Condition
- Reproductive neoplasms male malignant and unspecified
Health condition
Prostate cancer
Research involving
Sponsors and support
Intervention
- Other intervention
Outcome measures
Primary outcome
Experience of healthcare professionals and patients with the mainstreaming pathway in metastatic prostate cancer
Secondary outcome
Efficacy of the mainstreaming pathway in metastatic prostate cancer
Background summary
The use of germline genetic tests in patients with prostate cancer is increasing. International guidelines recommend to consider a germline genetic test in patients with metastatic prostate cancer. To improve access to genetic testing in patients with metastatic prostate cancer, mainstreaming of germline genetic testing is implemented in multiple hospitals in the Netherlands. In the mainstreaming pathway urologists, oncologists and nurse specialists discuss and order germline genetic tests themselves in patients with stage TxNxM1 prostate cancer. These healthcare professionals will be trained with the use of an online training module. The online training module can be completed in one hour and describes background knowledge and key information for counseling patients with metastatic prostate cancer. The aim of this study is to assess the experiences of patients and non-genetic healthcare professionals with this pathway with the use of questionnaires. Besides this, the efficacy of the mainstreaming pathway will be determined, based on the uptake of germline genetic testing, the diagnostic yield and the number of families with a germline variant that can yearly be identified with this pathway.
Study objective
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
Study design
Patients: T0 directly after healthcare professional discussed and ordered germline genetic test. T1 4 weeks after receiving genetic test result. T2 6 months after receiving genetic test result. Healthcare professionals: T0 before attending online training module. T1 3 months after attending online training module. T2 9 months after attending online training module.
Intervention
Mainstream germline genetic testing
Age
Inclusion criteria
1. Men with prostate cancer, stage TxNxM1; 2. Germline genetic test is discussed and ordered by non-genetic healthcare professional
Exclusion criteria
1. Tumor DNA-test; 2. Pretest counseling by clinical geneticist or genetic counselor; 3. Unable to understand, speak and write Dutch language
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9617 |
| Other | METC Utrecht : 20/577 |