No registrations found.
ID
Source
Brief title
Health condition
Sepsis
Bacteraemia/ bacteremia
Molecular diagnosis bacteria in blood
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary objectives:
1. To determine the diagnostic performance of five molecular assays for the detection of bacteraemia in patients.
2. To evaluate the relationship between the bacterial DNA load (BDL), quantitative culture and culture time-to-positivity in patients with bacteraemia.
Secondary outcome
Secondary objective:
1. To assess the putative applicability of the molecular assays in routine molecular diagnostics with regard to costs, hands on time and difficulty of the protocol in routine use.
Background summary
N/A
Study objective
The aim is to evaluate molecular assays for the detection and quantification of bacterial DNA in blood from patients with bacteraemia.
Study design
N/A
Intervention
N/A
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Inclusion criteria
- Age >= 18 years ;
- Bacteraemia with at least one blood culture with growth of Gram-negative bacteria or Gram-positive cocci in chain observed with microscopy;
- Bacteraemia with at least one blood culture with growth of Gram-positive cocci (in clusters) and at least one of the following syndromes suggestive of S. aureus infection: arthritis, wound infection, thrombophlebitis, meningitis, soft tissue infection, vertebral osteomyelitis, splenic abscess or other microbiological evidence for S. aureus infection.
Exclusion criteria
- Blood culture obtained >48 hours;
- Intravenous antibiotic therapy >48 hours;
- Haematological disorder;
- Anaemia (an Hb below 5.5 mmol/L);
- Participation in BLENT-study of patients with endocarditis;
- Previous participation in this study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3932 |
| NTR-old | NTR4094 |
| Other | : 12277 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |