No registrations found.
ID
Source
Brief title
Health condition
Nonaffective psychotic disorders:
schizophrenia, schizophreniform or schizoaffective disorder (295.x)
delusional disorder (297.1)
brief psychotic disorder (298.8)
psychotic disorder not otherwise specified (298.9).
Sponsors and support
Intervention
Outcome measures
Primary outcome
Social Functioning (Social Functioning Scale: average score), Timepoints: 0 months, 18 months, 24 months.
Secondary outcome
-Quality of Life (MANSA), Timepoints: 0 months, 18 months, 24 months.
-Psychotic Symptom Severity (PANSS / Psymate), Timepoints: 0 months, 9 months (Psymate only), 18 months, 24 months.
-Negative Affect (Psymate), Timepoints: 0 months, 9 months, 18 months, 24 months.
-Positive Affect (Psymate), Timepoints: 0 months, 9 months, 18 months, 24 months.
-Social Stress (Psymate), Timepoints: 0 months, 9 months, 18 months, 24 months.
-Social Cognition (Thematic Apperception Test), Timepoints: 0 months, 18 months, 24 months.
-Theory of Mind (Hinting Task), Timepoints: 0 months, 18 months, 24 months.
-Disease Awareness (Item G12 of the PANSS), Timepoints: 0 months, 18 months, 24 months.
-Substance abuse (Psymate), Timepoints: 0 months, 9 months, 18 months, 24 months.
-Negative symptoms (Subscale N of the PANSS), Timepoints: 0 months, 18 months, 24 months.
-Anxious symptoms (Item G2 of the PANSS), Timepoints: 0 months, 18 months, 24 months.
-Depressive symptoms (Item G4 of the PANSS), Timepoints: 0 months, 18 months, 24 months.
Background summary
Many patients with nonaffective psychotic disorders (NAPD) suffer impairments in social cognition and an emotional hyperreactivity to social stress, which often lead to decreased social functioning.
Mentalization Based Treatment for Psychosis (MBT-P) is developed to target impaired social cognition. It is a psychodynamic treatment rooted in attachment and cognitive theory developed for the treatment of NAPD. It is expected to improve social cognition and decrease social stress reactivity which in turn are expected to improve social functioning. MBT-P is further expected to increase quality of life and disease awareness, and to reduce substance abuse, positive, anxious and depressive symptoms.
Study objective
Patients who receive treatment as usual (TAU) plus mentalization-based treatment for psychosis (MBT-P) will show a greater improvement in social functioning than patients who receive TAU only.
This effect is mediated by an increase of social cognition and a decrease of social stress reactivity.
Study design
0 months: baseline measurement
9 months: halfway treatment measurment
18 months: end of treatment measurement
24 months: follow-up measurement
Intervention
-Mentalization Based Treatment for Psychosis
-Treatment as usual for NAPD: psychiatric consults, supportive therapy, wellfare aid, case management.
J.G. Weijers
Rivierduinen Institute for Mental Health Care
Sandifortdreef 19
Leiden 2333 ZZ
The Netherlands
0031-652582271
j.weijers@ggzleiden.nl
J.G. Weijers
Rivierduinen Institute for Mental Health Care
Sandifortdreef 19
Leiden 2333 ZZ
The Netherlands
0031-652582271
j.weijers@ggzleiden.nl
Inclusion criteria
- Age 18-55
- Informed consent
- Diagnosis of a nonaffective psychotic disorder
- In treatment for at least a year, but no longer than 10 years
Exclusion criteria
- Intellectual disabilities and/or illiteracy.
- A lack of mastery of the Dutch language.
- Severe addiction to such an extent that inpatient detoxification is necessary. After detoxification the patient is still eligible for participation in the study.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4588 |
| NTR-old | NTR4747 |
| Other | MEC AZM / MU : 13-3-066.5/ab |