No registrations found.
ID
Source
Brief title
Health condition
Pilot study: healthy volunteers only.
Sponsors and support
Intervention
Outcome measures
Primary outcome
From both the 90-min dynamic data and the 30-min static data, several values will be computed. These include NET binding potentials (BP), standardized uptake values (SUV) and K values for each region of interest (LC and projection areas), which will then be used to compute ratios using appropriate reference tissue models
Secondary outcome
Not applicable.
Background summary
This study is a pilot study in healthy volunteers to verify PET scan time reduction, after which in the intended future study the same procedure will be used to investigate the noradrenaline system in groups of patients with Alzheimer's disease, Parkinson's disease and Down syndrome.
Study objective
This pilot study is a feasibility study to verify a shortened scan time duration. We hypothesize that the 30-min protocol provides results as reliable as the 90-min protocol.
Study design
Each subject undergoes one PET scan.
Inclusion criteria
Age ≥ 50 years and < 80 years; willingness to cooperate and sign written informed consent.
Exclusion criteria
Past or present developmental disorder or psychiatric disorder; abnormal results on the MMSE (<27); (subjective) memory complaints; presence of any contra-indication for PET scanning; participation in PET study in the last 12 months; use of any medication that acts on the NA system; absence of signed informed consent form.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7923 |
| Other | METC UMCG : METC2019109 |