No registrations found.
ID
Source
Brief title
Health condition
Muscle protein synthesis; protein; milk; free amino acids
Sponsors and support
Intervention
Outcome measures
Primary outcome
muscle protein synthesis (MPS) rates
Secondary outcome
Secondary endpoints include whole-body protein metabolism (synthesis, breakdown, oxidation, and net balance)
Background summary
Previous studies suggest that the form of dietary protein that is ingested can differentially facilitate protein digestion and absorption, increase plasma AA availability, and thereby augment the postprandial muscle protein synthetic response. For example, a more rapid increase in circulating plasma AA concentrations has previously been reported after the ingestion of a protein hydrolysate when compared with an intact protein. However, no significant difference in postprandial muscle protein synthesis was observed following the ingestion of a protein hydrolysate when compared to an intact protein. The objective of this research is to assess the anabolic response following ingestion of milk and free amino acids in vivo in young adults.
Study objective
The ingestion of free amino acids will result in higher plasma amino acid concentrations, resulting in enhanced muscle protein synthesis rates when compared with the ingestion of milk.
Study design
muscle biopsies at: -120, 0, 120, 360
blood drawn at: -210, -120, -90, -60, -30, 0, 15, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 300, 360
Intervention
milk versus free amino acids
Inclusion criteria
1) Aged 18-35 y
2) BMI 18.5-27.5 kg/m2
3) Healthy, recreationally active, young adults
Exclusion criteria
1) Allergies to milk protein
2) Lactose intolerance
3) PKU disease
4) Smoking
5) Diagnosed diabetes
6) Diagnosed metabolic or intestinal disorders
7) A history of neuromuscular problems
8) Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
9) Participation in structured resistance exercise program
10) Pregnant
11) Hormone replacement therapy
12) Third generation oral contraceptives
13) Strict vegetarian
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6764 |
| NTR-old | NTR6941 |
| Other | NL63767.068.17 : METC173047 |