No registrations found.
ID
Source
Brief title
Health condition
Long-term memory.
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary endpoint is the behavioral score on a set of memory paradigms, namely a verbal learning task, a picture memory task, and a spatial memory task. Furthermore, the brain activity (EEG and event-related potentials) will be recorded during those tasks.
Secondary outcome
The behavioral response and brain activity during a choice reaction time task is recorded in order to find out whether the medication also has sedative effects.
Background summary
N/A
Study objective
Rivastigmine can reverse a memory impairment that is induced by biperiden, which will be seen both behaviorally and in the EEG.
Study design
N/A
Intervention
Participants will participate on 4 separate test days and will be administered either rivastigmine, biperiden, a combination, or a placebo. The order of treatment will be counterbalanced.
Dept. of Neuropsychology and Psychopharmacology
PO Box 616
Anke Sambeth
Maastricht 6200 MD
The Netherlands
0031-(0)43-3881757
anke.sambeth@psychology.unimaas.nl
Dept. of Neuropsychology and Psychopharmacology
PO Box 616
Anke Sambeth
Maastricht 6200 MD
The Netherlands
0031-(0)43-3881757
anke.sambeth@psychology.unimaas.nl
Inclusion criteria
1. Male or female;
2. 18 to 35 years of age;
3. healthy (i.e. absence of all exclusion criteria);
4. body mass index between 18.5 and 30;
5. willingness to sign an informed consent.
Exclusion criteria
1. History of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological, or psychiatric ilness;
2. excessive drinking (> 20 glasses of alcohol containing beverages a week);
3. pregnancy or lactation;
4. use of medication other than oral contraceptives;
5. use of recreational drugs from 2 weeks before the experiment until the end of the study;
6. any sensory or motor deficits which could reasonably be expected to affect test performance;
7. having a first-degree relative with a psychiatric disorder.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1070 |
| NTR-old | NTR1103 |
| Other | VENI : grant nr. 451-07-011 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |