No registrations found.
ID
Source
Brief title
Health condition
Alzheimer's disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
Change in impairments after two years of follow up in activities of daily living as measured by the Interview for Deterioration in Daily life in dementia (IDDD).
Secondary outcome
Change in cognitive functioning, behavioral abnormalities, blood pessure, body weight. New lesions on MRI after two years.
Background summary
Frequently patients with a clinical diagnosis of Alzheimer's disease also harbour cerebrovascular lesions on neuroimaging. It is not clear to what extent these lesions contribute to (1) functional impairments, and (2) the prognosis of these patients. In this open multicentre clinical trial the hypothesis is tested that intensive vascular care is efficacious in these patients, resulting in slower deterioration after a follow up of two yeras in patients receiving such care, in comparison to patients receiving standard care.
Study objective
Intensive vascular care, aimed at secundary prevention of cerebrovascular disease, is efficacious in patients with Alzheimer's disease that have vascular lesions on MRI.
Study design
N/A
Intervention
Multicomponent intervention consisting of a combination of measures aimed at prevention of cerebrovascular disease (platelet aggregation inhibitors, statin, strict regulation of blood pressure, diabetes, life style interventions concerning smoking, body weight, excercise). Patients in the control group will recieve 'regular care' i.e. less frequent visits, without specific attention to vascular risk factors.
P.O. Box 22660
W.A. Gool, van
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5664044
w.a.vangool@amc.uva.nl
P.O. Box 22660
W.A. Gool, van
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5664044
w.a.vangool@amc.uva.nl
Inclusion criteria
Patients with early Alzheimer's disease according to clinical criteria, that have on MRI either cerebral infarcts or significant white matter abnormalities.
Exclusion criteria
1. Severe dementia;
2. Limited life expectancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL590 |
| NTR-old | NTR646 |
| Other | : N/A |
| ISRCTN | ISRCTN74902933 |