No registrations found.
ID
Source
Brief title
Health condition
Sjogrens Syndroom
auto-immuun aandoeningen
Xerostomie
Sponsors and support
Intervention
Outcome measures
Primary outcome
Obtained material will be used to elucidate primarily the B-cell pathogenesis of Sjogren's Syndrome. Using immunohistochemistry, RNS and protein analysis, the B-cel receptor (BCR), T-cell receptor (TCR), a B-cell stimulating cytokine (APRIL) and the interaction between different immune cell populations and cytokines will be studied
Secondary outcome
N/A
Background summary
Country of recruitment: The Netherlands.
In all patients undergoing diagnostic lower lip biopsies, salivary gland tissue will be collected and studied.
Study objective
To gain more insight into the pathogenetic processes involved in Sjogrens Syndrome(SS) bij analyzing the infiltrate and structural changes in salivary glands of SS patients and compare these findings to those in other (aspecific) inflammatory and non-inflammatory salivary gland diseases.
Study design
One, after lipbiopsy.
Intervention
In all patients undergoing diagnostic lower lip biopsies, salivary gland tissue will be collected and processed using a standard protocol for formalin fixation to allow standard histological evaluation for diagnostic purposes. Samples will also be frozen in Tissue-Tek OCT compound for immunohistochemistry (IHC) or snap frozen for PCR, micro-array, T Cell Receptor (TCR) and B Cell Receptor (BCR) analysis, and protein expression analysis. Tissues will be analyzed using these techniques for exploratory analysis in relationship to the pathogenesis of SS.
P.O. Box 22660
P.P. Tak
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5662171
p.p.tak@amc.nl
P.O. Box 22660
P.P. Tak
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5662171
p.p.tak@amc.nl
Inclusion criteria
Patients undergoing lower lip biopsies for diagnostic purposes.
Exclusion criteria
N/A
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2339 |
| NTR-old | NTR2446 |
| Other | MEC AMC : 10/011 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |